Living donor liver transplantation from a donor previously treated with interferon for hepatitis C virus: a case report
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Selecting a marginal donor in liver transplantation (LT) remains controversial but is necessary because of the small number of available donors.
A 46-year-old Japanese woman was a candidate to donate her liver to her brother, who had decompensated liver cirrhosis of unknown origin. Eight years before the donation, she had a mild liver dysfunction that was diagnosed as a hepatitis C virus (HCV) infection (serotype 2). She had received anti-viral therapy with interferon α-2b three times weekly for 24 weeks and had a sustained viral response (SVR). A biopsy of her liver before the donation showed normal findings without any active hepatitis, and her serum was negative for HCV-RNA. Only 67 patients have undergone LT from a cadaveric donor in Japan. The family in this case decided to have living donor LT. A careful selection for the liver graft donation was made; however, since she was the only candidate, we approved her as a living donor. She was discharged nine days after the liver donation. Her liver function recovered immediately. A computed tomography scan showed sufficient liver regeneration one year later. Her brother also had good liver function after LT and had no HCV infection 48 months after surgery and no de novo malignancy. Neither of the siblings has developed an HCV infection.
A patient with SVR status after interferon therapy might be considered a candidate for living donor LT but only if there are no other possibilities of LT for the recipient. A careful follow-up of the donor after donation is needed. The recipient also must have a very close follow-up because it is difficult to predict what might happen to the graft with post-transplant immunosuppression.
KeywordsLive Donor Liver Transplantation Interferon Therapy Sustained Viral Response Deceased Donor Liver Transplantation Mild Liver Dysfunction
deceased donor liver transplantation
hepatitis B virus
hepatitis C virus
living donor liver transplantation
sustained viral response.
The number of deceased donor liver transplantations (DDLTs) in Japan is extremely small. There were 67 cases between February 1999 and January 2010, according to the Japan Organ Transplant Network . Therefore, living donor liver transplantation (LDLT) is the most frequent treatment option for patients with end-stage liver disease in Japan. The main advantage of LDLT over DDLT is that the donor can be completely evaluated, before the operation, to exclude many medical problems. However, the indications for a living donor should be strict and the risk to the donor must be avoided with the greatest care. Donors with possibly morbid liver conditions, including fatty infiltration or a history of viral hepatitis, and older donors offer "marginal grafts", which should be used only after very careful evaluation. A hepatitis B virus (HBV) core antibody seropositive donor can be accepted as long as HBV surface antigen is seronegative and anti-viral treatment is administered to the recipient after transplantation [2, 3]. In this way, donor safety also is established, according to several reports of this type of case [4, 5, 6]. Some investigators reported that the patients obtained a sustained viral response (SVR) after interferon therapy showed that there was no tendency to develop fibrotic liver in the future [7, 8]. HCV-RNA was not detected in 88% of the serum and liver biopsies of patients with an SVR . The infection rate of the recipient from an HCV-positive graft should be low after LT. The rate of carcinogenesis has increased at an annual rate of 0.11% after an SVR was maintained with anti-viral therapy . Using a graft with a positive hepatitis C virus (HCV) antibody although HCV-RNA was not detected in the blood remains controversial in Western countries [11, 12, 13]. To the best of our knowledge, there is no actual data that shows the outcome of liver transplantation with a graft from patients who acquire an SVR after successful anti-viral therapy. Here, we report the case of a living donor who had an SVR before LDLT. The case is described and discussed in detail.
Selecting a living donor in this case might be controversial, although a marginal donor can also sometimes be a candidate. The risks in this case included HCV transmission to the recipient, HCV reactivation in the recipient after LDLT, and donor risk during surgery. A number of studies have reported that the results with recipients of an HCV-infected graft were comparable to those of recipients of an HCV-negative graft [11, 12, 13]. The Scientific Registry of the United Network for Organ Sharing reported that the survival rate of 96 patients was significantly higher in the recipients of HCV-positive grafts than in recipients of HCV-negative grafts . These results demonstrated that the use of an HCV-positive graft may also be acceptable in cadaveric LT. In contrast, an HCV-infected graft was not acceptable in LDLT. Patients who have HCV and who acquire an SVR after interferon therapy can be considered living donor candidates.
In this case, it was difficult to determine the indications for the donor selection before transplantation. Patients with serotype 2 HCV are more likely to achieve an SVR after interferon therapy than those with serotype 1. Our donor achieved an SVR of HCV. She and her brother were fully informed of the risk of peri-operative complications and the possibility that he would receive an HCV infection from the graft although she had obtained an SVR after anti-viral therapy. In theory, it is unlikely that a recipient would develop a viral infection from a graft that achieved an SVR.
We report a case of LDLT from a donor previously treated with interferon for HCV. A patient with SVR status after interferon therapy might be considered a candidate for LDLT only if there are no other possibilities of LT for the recipient. A careful follow-up of the donor after donation is needed. The recipient also must have a very close follow-up because it is difficult to predict what might happen to the graft with post-transplant immunosuppression.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
- 4.Hwang S, Moon DB, Lee SG, Park KM, Kim KH, Ahn CS, Lee YJ, Chu CW, Yang HS, Cho SH, Oh KB, Ha TY, Min PC: Safety of anti-hepatitis B core antibody-positive donors for living-donor liver transplantation. Transplantation. 2003, 75: S45-48. 10.1097/01.TP.0000047030.38665.0D.CrossRefPubMedGoogle Scholar
- 6.Van Thiel DH, De Maria N, Colantoni A, Friedlander L: Can hepatitis B core antibody positive livers be used safely for transplantation: hepatitis B virus detection in the liver of individuals who are hepatitis B core antibody positive. Transplantation. 1999, 68: 519-522. 10.1097/00007890-199908270-00013.CrossRefPubMedGoogle Scholar
- 7.Shiratori Y, Imazeki F, Moriyama M, Yano M, Arakawa Y, Yokosuka O, Kuroki T, Nishiguchi S, Sata M, Yamada G, Fujiyama S, Yoshida H, Omata M: Histologic improvement of fibrosis in patients with hepatitis C who have sustained response to interferon therapy. Ann Intern Med. 2000, 132: 517-524.CrossRefPubMedGoogle Scholar
- 9.Larghi A, Tagger A, Crosignani A, Ribero ML, Bruno S, Portera G, Battezzati PM, Maggioni M, Fasola M, Zuin M, Podda M: Clinical significance of hepatic HCV RNA in patients with chronic hepatitis C demonstrating long-term sustained response to interferon-alpha therapy. J Med Virol. 1998, 55: 7-11. 10.1002/(SICI)1096-9071(199805)55:1<7::AID-JMV2>3.0.CO;2-7.CrossRefPubMedGoogle Scholar
- 11.Saab S, Ghobrial RM, Ibrahim AB, Kunder G, Durazo F, Han S, Farmer DG, Yersiz H, Goldstein LI, Busuttil RW: Hepatitis C positive grafts may be used in orthotopic liver transplantation: a matched analysis. Am J Transplant. 2003, 3: 1167-1172. 10.1034/j.1600-6143.2003.00189.x.CrossRefPubMedGoogle Scholar
- 13.Marroquin CE, Marino G, Kuo PC, Plotkin JS, Rustgi VK, Lu AD, Edwards E, Taranto S, Johnson LB: Transplantation of hepatitis C-positive livers in hepatitis C-positive patients is equivalent to transplanting hepatitis C-positive livers. Liver Transplant. 2001, 7: 762-768. 10.1053/jlts.2001.27088.CrossRefGoogle Scholar
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