Efficacy of chordal cutting in alleviating ischemic mitral regurgitation: insights from 3-dimensional echocardiography
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Ischemic mitral regurgitation often complicates severe ischemic heart disease and adversely affects the prognosis in these patients. There is wide variation in the clinical spectrum of ischemic mitral regurgitation due to varying location and chronicity of ischemia and anomalies in annular and ventricular remodeling. As a result, there is lack of consensus in treating these patients. Treatment has to be individualized for each patient. Most of the available surgical options do not consistently correct this condition in all the patients. Chordal cutting is one of the newer surgical approaches in which cutting a limited number of critically positioned basal chordae have found success by relieving the leaflet tethering and thereby improving the coaptation of leaflets. Three-dimensional echocardiography is a potentially valuable tool in identifying the specific pattern of tethering and thus the suitability of this procedure in a given clinical scenario.
A 66-year-old man with cardiomyopathy and ischemic mitral regurgitation presented to us with the features of congestive heart failure. The three-dimensional echocardiography revealed severe mitral regurgitation associated with the tethering of the lateral (P1) and medial (P3) scallops of the posterior leaflet of the mitral valve due to secondary chordal attachments. The ejection fraction was only 15% with severe global systolic and diastolic dysfunction. Mitral regurgitation was successfully corrected with mitral annuloplasty and resection of the secondary chordae tethering the medial and lateral scallops of the posterior leaflet of the mitral valve.
Cutting the second order chordae along with mitral annuloplasty could be a novel method to remedy Ischemic mitral regurgitation by relieving the tethering of the valve leaflets. The preoperative three-dimensional echocardiography should be considered in all patients with Ischemic mitral regurgitation to assess the complex three-dimensional interactions between the mitral valve apparatus and the left ventricle. This aids in timely surgical planning.
KeywordsMitral Valve Mitral Regurgitation Mitral Leaflet Posterior Leaflet Ischemic Mitral Regurgitation
Ischemic Mitral regurgitation (IMR) continues to be a complex surgical problem. Choosing the most optimal therapy remains a challenging issue in cardiac surgery. There is wide variation in the clinical spectrum of IMR due to varying location and chronicity of ischemia and anomalies in annular and ventricular remodeling. As a result, there is lack of consensus in treating these patients. Treatment has to be individualized for each patient. Three-dimensional (3-D) echocardiography is a potentially valuable tool in gaining the mechanistic insights into the pathogenesis of IMR by precise evaluation of the complex three-dimensional interactions between the mitral valve apparatus and the left ventricle. Noting the exact geometric perturbations in each individual clinical setting will enable us in the rational design of the specific repair methods and in making the choice amongst the different techniques and devices that are currently available. We present a case of severe IMR in which ring annuloplasty combined with chordal cutting was planned based on the findings on 3-D echocardiography with a good result.
Showing the pre- and post-operative measurements of Mitral valve
Valve Area (cm2)
Annular Volume (mL)
Ischemic mitral regurgitation (IMR) often complicates severe coronary artery disease and has a negative impact on the long term survival of these patients. Several anatomical and pathophysiological changes play a role in the genesis of IMR. The initiating event is an ischemic insult to the three dimensional interaction between the leaflets, annulus, subvalvular apparatus and left ventricular wall. The remodeling of the ischemic left ventricle results in increase in the sphericity index [1, 2], mitral annular dilatation [3, 4], and outward displacement of the papillary muscles with the subsequent tethering and tenting of the mitral leaflets into the left ventricle [5, 6, 7, 8]. All these have been implicated in the pathogenesis of IMR. In the setting of left ventricular systolic dysfunction, there is also reduction in the force available to close the leaflets in opposition to the increased tethering which further complicates the IMR [9, 10, 11]. Mitral regurgitation in turn leads to a vicious cycle of volume overload, with further progression of annular dilation, LV remodeling and increased severity of symptoms of congestive heart failure. Mitral regurgitation is an independent predictor of mortality and adversely affects the survival and functional status [12, 13, 14, 15].
Normal mitral valve has a unique morphology with a non-planner saddle shape and curved mitral leaflets. [16, 17, 18]. The 3-dimensional configuration of the curved mitral annulus is difficult to investigate using conventional 2-D echocardiography as the images represent a single plane which requires mental reconstruction of the 2-dimensional views [16, 17, 19]. Characterization of the mitral valve apparatus using 3-D echocardiography has shed a new light on the pathophysiology of mitral regurgitation [5, 6, 7, 8, 9], [20, 21, 22, 23]. One of the important predictors of IMR is tenting of the mitral valve [5, 6, 7, 8, 9, 24]. Tenting results from tethering of the leaflets, which is an end result of the perturbation in the complex three-dimensional interactions between the mitral valve apparatus and the left ventricle. The accuracy and variability of conventional 2-D echocardiography in these patients is often limited as it requires geometrical assumptions of 2-dimensional views. As a result some spatial relations and different structural features can be perceived erroneously even by the experienced echocardiographers. This would call for an unexpected modification in the technique of repair in the operating room, where the surgeon is challenged by limited time, operating field and non-physiological condition of the heart being devoid of blood which does not mimic the normal hemodynamic situation. In this clinical setting, the 3-D echocardiography is a potentially valuable tool as it creates images, resembling the true anatomy of the heart. By choosing a cutting plane and reconstructing the image beyond this plane the heart can be opened as if by a surgeon. This enhances the ability to assess the spatial relations between cardiac structures and also the specific tethering patterns.
Remodeling anunuloplasty using an undersized ring is the standard therapeutic approach for MR. It reduces antero-posterior valve dimensions by bringing the posterior annulus forward thus increases coaptating surface of the leaflets [1, 25, 26, 27]. However, several studies have demonstrated that MR can persist or recur even after ring annuloplasty. This could be due to the fact that annuloplasty doesn't sufficiently address the tethering of the leaflets by the remodeled ventricle [28, 29, 30, 31]. Chordal cutting, papillary muscle imbrication in combination with LV volume reduction, Septal anterior ventricular exclusion (SAVE), papillary muscle sling, ventricular reconstruction, pericardial patch enlargement of the restricted PML are some of the strategies that have shown success in limited number of patients [32, 33]. Chordal cutting approaches championed by Messas et al  have shown promising results in several experimental and clinical studies [32, 34, 35, 36]. In these studies, cutting a limited number of critically positioned basal chordae has shown to improve the coaptation by relieving the leaflet tethering and thereby reduce chronic persistent IMR even in the remodeled ventricle. Subsequently, this therapeutic option was challenged by another experimental study by Rodriguez et al  in which the chordal cutting did not relieve IMR. This controversy could be better understood by examining the specific valvular geometry through 3-D echocardiography.
Technical limitations of 3-D echocardiography
The 3-D images were actually reconstructed from the multiplanar 2-D images taken over several cardiac cycles. Therefore, 3-D TEE reconstructions depend critically on the quality of the original 2D sectional images. There is a risk of introducing artifacts from patient respiration, motion and irregular movements of the heart during arrhythmias. Analysis was performed off-line and required tedious manual tracing of endocardial borders. The time required for reconstruction is an important factor limiting its applicability in the operating room . However, the past years have seen significant development in transducer technology, allowing pyramidal shaped blocks to be acquired in real time. It is now possible to image an entire ventricle or valve and analyze it online, thus obviating the need for complicated and time-consuming reconstructions. However, Images obtained by Real-time 3-D echocardiography are of poorer quality compared to conventional 2-D echocardiography [21, 22, 23, 39].
All patients with IMR should be considered for pre-operative 3D TEE evaluation for timely surgical planning and also for intra-operative 3D TEE imaging and reconstruction to assess the dynamic changes that occur intra-operatively.
Written consent was obtained from the patient for publication of the study. We have no funding for this study as it is a case report.
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