Stage-variations of anandamide hydrolase activity in the mouse uterus during the natural oestrus cycle

  • Francesca G Klinger
  • Natalia Battista
  • Massimo De Felici
  • Mauro Maccarrone
Open Access


Recent studies have demonstrated that the endogenous cannabinoids are important modulators of fertility in mammals. In particular, a role of the endocannabinoid system in early stages of embryo development, oviductal transport of embryos, pregnancy maintenance and labour has been demonstrated in rodents and/or in humans. In the present paper, we report the analysis of FAAH activity and protein content in the mouse uterus as a function of the natural oestrus cycle stages. Variations of FAAH activity are discussed in relationship to changes in sex steroid levels and to the possible action of AEA on remodelling of uterine tissues.



This work was supported by the Italian MIUR PRIN grant 2004–2005.


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© Klinger et al; licensee BioMed Central Ltd. 2006

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Authors and Affiliations

  • Francesca G Klinger
    • 1
  • Natalia Battista
    • 2
  • Massimo De Felici
    • 1
  • Mauro Maccarrone
    • 2
    • 3
  1. 1.Department of Public Health and Cell BiologyUniversity of Rome Tor VergataRomeItaly
  2. 2.Department of Biomedical SciencesUniversity of TeramoTeramoItaly
  3. 3.IRCCS C. Mondino, Mondino-Tor Vergata Center for Experimental NeurobiologyRomeItaly

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