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Comparative analysis of follicle morphology and oocyte diameter in four mammalian species (mouse, hamster, pig, and human)

  • Jeanine Griffin
  • Benjamin R Emery
  • Ivan Huang
  • C Matthew Peterson
  • Douglas T Carrell
Open Access
Research

Abstract

Background

Laboratory animals are commonly used for evaluating the physiological properties of the mammalian ovarian follicle and the enclosed oocyte. The use of different species to determine the morphological relationship between the follicle and oocyte has led to a recognizable pattern of follicular stages, but differences in follicle size, oocyte diameter and granulosa cell proliferation are not consistent across the different species. In an effort to better understand how these differences are expressed across multiple species, this investigation evaluates oocyte and follicle diameters and granulosa cell proliferation in the mouse, hamster, pig, and human.

Methods

Histological sections of ovaries from the mouse, hamster, pig, and human were used to calculate the diameter of the oocyte and follicle and the number of granulosa cells present at pre-determined stages of follicular development. A statistical analysis of these data was performed to determine the relationship of follicular growth and development within and between the species tested.

Results

These data have revealed that the relationships of the features listed are tightly regulated within each species, but they vary between the species studied.

Conclusion

This information may be useful for comparative studies conducted in different animal models and the human.

Notes

Acknowledgements

None.

References

  1. 1.
    Gougeon A: Regulation of ovarian follicular development in primates: facts and hypotheses. Endocr Rev. 1996, 17 (2): 121-155. 10.1210/er.17.2.121.CrossRefPubMedGoogle Scholar
  2. 2.
    Fortune JE: Ovarian follicular growth and development in mammals. Biol Reprod. 1994, 50 (2): 225-232. 10.1095/biolreprod50.2.225.CrossRefPubMedGoogle Scholar
  3. 3.
    Hirshfield AN: Development of follicles in the mammalian ovary. Int Rev Cytol. 1991, 124: 43-101.CrossRefGoogle Scholar
  4. 4.
    Peters H: The development of the mouse ovary from birth to maturity. Acta Endocrinol (Copenh). 1969, 62 (1): 98-116.Google Scholar
  5. 5.
    Pedersen T, Peters H: Proposal for a classification of oocytes and follicles in the mouse ovary. J Reprod Fertil. 1968, 17 (3): 555-557.CrossRefGoogle Scholar
  6. 6.
    Wassarman PM: Oogenesis. Reproductive Endocrinology, Surgery, and Technology. Edited by: Adashi EY, Rock JA, Rosenwaks Z. 1996, Philadelphia , Lippincott-Raven Publishers, 342-357.Google Scholar
  7. 7.
    Gougeon A: Dynamics of human follicular growth: Morphologic, dynamic, ad funcitonal aspects. The Ovary. 2004, ElsevierGoogle Scholar
  8. 8.
    Knigge KM, Leathem JH: Growth and atresia of follicles in the ovary of the hamster. Anat Rec. 1956, 124 (4): 679-707. 10.1002/ar.1091240406.CrossRefPubMedGoogle Scholar
  9. 9.
    Wassarman PM, Josefowicz WJ: Oocyte development in the mouse: an ultrastructural comparison of oocytes isolated at various stages of growth and meiotic competence. J Morphol. 1978, 156 (2): 209-235. 10.1002/jmor.1051560206.CrossRefPubMedGoogle Scholar
  10. 10.
    Fricke PM, Ford JJ, Reynolds LP, Redmer DA: Growth and cellular proliferation of antral follicles throughout the follicular phase of the estrous cycle in Meishan gilts. Biol Reprod. 1996, 54 (4): 879-887. 10.1095/biolreprod54.4.879.CrossRefPubMedGoogle Scholar
  11. 11.
    Gougeon A: Dynamics of follicular growth in the human: a model from preliminary results. Hum Reprod. 1986, 1 (2): 81-87.CrossRefGoogle Scholar
  12. 12.
    van den Hurk R, Zhao J: Formation of mammalian oocytes and their growth, differentiation and maturation within ovarian follicles. Theriogenology. 2005, 63 (6): 1717-1751. 10.1016/j.theriogenology.2004.08.005.CrossRefPubMedGoogle Scholar
  13. 13.
    Delforge JP, Thomas K, Roux F, Carneiro de Siqueira J, Ferin J: Time relationships between granulosa cells growth and luteinization, and plasma luteinizing hormone discharge in human. 1. A morphometric analysis. Fertil Steril. 1972, 23 (1): 1-11.CrossRefGoogle Scholar
  14. 14.
    Evans AC: Characteristics of ovarian follicle development in domestic animals. Reprod Domest Anim. 2003, 38 (4): 240-246. 10.1046/j.1439-0531.2003.00439.x.CrossRefPubMedGoogle Scholar
  15. 15.
    Gougeon A: Ovarian follicular growth in humans: ovarian ageing and population of growing follicles. Maturitas. 1998, 30 (2): 137-142. 10.1016/S0378-5122(98)00069-3.CrossRefPubMedGoogle Scholar
  16. 16.
    Hunter MG, Wiesak T: Evidence for and implications of follicular heterogeneity in pigs. J Reprod Fertil Suppl. 1990, 40: 163-177.PubMedGoogle Scholar
  17. 17.
    Mermillod P, Oussaid B, Cognie Y: Aspects of follicular and oocyte maturation that affect the developmental potential of embryos. J Reprod Fertil Suppl. 1999, 54: 449-460.PubMedGoogle Scholar
  18. 18.
    Trounson A, Anderiesz C, Jones G: Maturation of human oocytes in vitro and their developmental competence. Reproduction. 2001, 121 (1): 51-75. 10.1530/rep.0.1210051.CrossRefPubMedGoogle Scholar
  19. 19.
    Eppig JJ, O'Brien MJ: Development in vitro of mouse oocytes from primordial follicles. Biol Reprod. 1996, 54 (1): 197-207. 10.1095/biolreprod54.1.197.CrossRefPubMedGoogle Scholar
  20. 20.
    Hunter MG: Oocyte maturation and ovum quality in pigs. Rev Reprod. 2000, 5 (2): 122-130. 10.1530/ror.0.0050122.CrossRefPubMedGoogle Scholar
  21. 21.
    Gougeon A, Chainy GB: Morphometric studies of small follicles in ovaries of women at different ages. J Reprod Fertil. 1987, 81 (2): 433-442.CrossRefGoogle Scholar
  22. 22.
    Hoage TR, Cameron IL: Folliculogenesis in the ovary of the mature mouse: a radioautographic study. Anat Rec. 1976, 184 (4): 699-709. 10.1002/ar.1091840409.CrossRefPubMedGoogle Scholar
  23. 23.
    Morbeck DE, Esbenshade KL, Flowers WL, Britt JH: Kinetics of follicle growth in the prepubertal gilt. Biol Reprod. 1992, 47 (3): 485-491. 10.1095/biolreprod47.3.485.CrossRefPubMedGoogle Scholar

Copyright information

© Griffin et al; licensee BioMed Central Ltd. 2006

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Authors and Affiliations

  • Jeanine Griffin
    • 1
  • Benjamin R Emery
    • 1
    • 2
  • Ivan Huang
    • 3
  • C Matthew Peterson
    • 3
  • Douglas T Carrell
    • 1
    • 2
    • 3
  1. 1.Andrology and IVF Laboratories, Division of Urology, Department of SurgeryUniversity of Utah School of MedicineSalt Lake CityUSA
  2. 2.Department of PhysiologyUniversity of Utah School of MedicineSalt Lake CityUtahUSA
  3. 3.Division of Reproductive Endocrinology, Department of Obstetrics and GynecologyUniversity of Utah School of MedicineSalt Lake CityUtahUSA

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