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Retrovirology

, 9:P33 | Cite as

Molecular epidemiology of HIV-1 subtype B in the Basque Country (Spain)

  • Juan Angel Patiño
  • Miguel M Thomson
  • Fernando González-Candelas
Open Access
Poster presentation
  • 651 Downloads

Keywords

Mann Whitney Test Resistance Mutation Molecular Clock Molecular Epidemiology Basque Country 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

The goal of this work was to study the HIV-1 subtype B epidemic in the Basque Country (Spain). For this, we used HIV samples submitted for genotypic testing of anti-retroviral resistance mutations from 2005 until 2008. Consequently, 2115 HIV-1 sequences comprising protease and retrotranscriptase (PR/RT) coding regions were analyzed. HIV transmission groups were identified by phylogenetic analysis. The 10 largest such groups were subsequently subjected to Bayesian phylogenetic and coalescent reconstructions, using a relaxed molecular clock model.

The results obtained show that these groups have been long-standing: most of them were originated in the late 70s or early 80s, and none after the year 2000. Most of these groups comprise both intravenous drug users (UDIs) and people who got infected through unprotected heterosexual sex (HTs). MSM clades were also represented in the sampled population. By comparing different demographic models, it was concluded that all the transmission groups are growing in an exponential manner. Time between infections was significantly lower in MSM groups than in those mainly containing IDUs (P-value < 0.05 in the Mann Whitney test).

In conclusion, this work suggests that in the near future the HIV-1 subtype B epidemics in the Basque Country will be characterized by a growth of the existing transmission groups. Due to the high diversity of these clusters, it is necessary to design campaigns for HIV prevention focused on the different risk groups.

Copyright information

© Patiño et al; licensee BioMed Central Ltd. 2012

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Authors and Affiliations

  • Juan Angel Patiño
    • 1
  • Miguel M Thomson
    • 1
  • Fernando González-Candelas
    • 1
  1. 1.Csisp-University of ValenciaValenciaSpain

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