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Retrovirology

, 8:O22 | Cite as

Distinct activities of HTLV-1 Tax1 from HTLV-2 Tax2 play key roles in pathogenesis

  • Masahiro Fujii
  • Masahiko Takahashi
  • Manami Yoshita
  • Michitaka Imai
  • Masaya Higuchi
Open Access
Oral presentation
  • 511 Downloads

Keywords

Persistent Infection Oxidative Stress Response Amino Acid Similarity Acid Similarity Distinct Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

While human T cell leukemia virus type 1 (HTLV-1) is an etiological agent of adult T-cell leukemia (ATL), its close relative HTLV-2 is not associated with any leukemia. HTLV-1 and HTLV-2 encode Tax1 and Tax2 proteins, respectively, which are essential for immortalization of T-cells by the respective viruses, thereby persistent infection. Tax1 and Tax2 have more than 75% amino acid similarities, but we show here that Tax1 and Tax2 have multiple distinct activities. Tax1 induced IL-2-independent growth of a T-cell line CTLL-2 more efficiently than Tax2. By contrast, Tax2 immortalized human T-cells in the presence of IL-2 more efficiently than Tax1. These results suggest that HTLV-1 and HTLV-2 have distinct IL-2 requirements to immortalize T-cells. We also found that Tax1 altered cellular oxidative stress response. Arsenite, a pro-oxidant, induced stress granule (SG) formation, which functions as a protective role against oxidant-induced cell damages, but the formation was inhibited by Tax1. We will discuss these findings in terms of the HTLV-1-specific pathogenesis.

Copyright information

© Fujii et al; licensee BioMed Central Ltd. 2011

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Authors and Affiliations

  • Masahiro Fujii
    • 1
  • Masahiko Takahashi
    • 1
  • Manami Yoshita
    • 1
  • Michitaka Imai
    • 1
  • Masaya Higuchi
    • 1
  1. 1.Niigata UniversityJapan

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