Retrovirology

, 8:A44 | Cite as

Persistent high HTLV-1 proviral load in a patient with complete remission of Adult T-cell leukemia/lymphoma (ATL)

  • Andrea Mangano
  • Patricia Costantini
  • Natalia Altamirano
  • Griselda De Stefano
  • Paula Aulicino
  • Luisa Sen
Open Access
Meeting abstract
  • 759 Downloads

Keywords

Lymphoma Interferon Complete Remission Lamivudine Zidovudine 

ATL is a highly aggresive lymphoproliferative disorder caused by HTLV-1. While HTLV-1 proviral load increase with progression of the disease, changes following therapy in ATL have not been well characterized. We present a case of ATL in complete remission with persistent high HTLV-1 proviral load.

A 49-year-ol man was diagnosed as HTLV-1 carrier after a blood donation in 2004. He was born in Buenos Aires, a non-endemic area of Argentina. Four years later, he was diagnosed with T-cell lymphoma but rapidly blast cells were observed in peripheral blood and it was classified as T-cell leukemia . Chemotherapy was started in November 2008 and reached complete remission after 6 cycles. In May 2009, Interferon and zidovudine was started as maintainance therapy. HTLV-1 proviral load were log10 5.5 copies/106 PBMCs and log10 5.3 copies/106 PBMCs in September 2009 and December 2009, respectively. Due to persistent high proviral load, the therapy was changed to pegylated interferon, tenofovir and lamivudine (3TC). Proviral load levels were also high at 4 and 14 months on treatment (log10 5.45 copies/106 PBMCs and log10 5.35 copies/106 PBMCs, respectively).

With the combination of interferon and reverse transcriptase inhibitors for more than one year, the patient is in complete remission, 27 month after the diagnosis, despite the fact that he never even attained reduction of HTLV-1 proviral load.

Copyright information

© Mangano et al; licensee BioMed Central Ltd. 2011

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Authors and Affiliations

  • Andrea Mangano
    • 1
  • Patricia Costantini
    • 2
  • Natalia Altamirano
    • 1
  • Griselda De Stefano
    • 3
  • Paula Aulicino
    • 1
  • Luisa Sen
    • 1
  1. 1.Laboratorio de Biología Celular y RetrovirusHospital de Pediatría “J.P. Garrahan”Ciudad Autónoma de Buenos AiresArgentina
  2. 2.División de InfectologíaHospital Angel H. RoffoCiudad Autónoma de Buenos AiresArgentina
  3. 3.División de HematologíaHospital Angel H. RoffoCiudad Autónoma de Buenos AiresArgentina

Personalised recommendations