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Retrovirology

, 8:A41 | Cite as

Immunohistochemical and virological features of HTLV-1-associated myosites: a study of 13 patients from West Indies and Africa

  • Marion Desdouits
  • Olivier Cassar
  • Thierry Maisonobe
  • Alexandra Desrames
  • Achille Aouba
  • Olivier Hermine
  • Jacqueline Mikol
  • Marc Polivka
  • Isabelle Penisson-Besnier
  • Pascale Marcorelles
  • Fabien Zagnoli
  • Thomas Papo
  • Arnaud Lacour
  • Zahir Amoura
  • Julien Haroche
  • Patrick Chérin
  • Antonio Texeira
  • Anne-Sophie Morin
  • Franck Mortreux
  • Eric Wattel
  • Michel Huerre
  • Marie-Christine Cumont
  • Huot Khun
  • Sylviane Bassot
  • Sandra Martin-Latil
  • Graham Taylor
  • Antoine Gessain
  • Simona Ozden
  • Pierre-Emmanuel Ceccaldi
Open Access
Meeting abstract

Keywords

Human Leukocyte Antigen Uveitis Myositis Inclusion Body Myositis Proviral Load 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Background

HTLV-1 is associated with the onset of various inflammatory diseases such as HTLV-1 Associated Myelopathy / Tropical Spastic Paraparesis, uveitis, infective dermatitis or inflammatory myopathies. Here, we aimed to get new insights into the pathogenesis of HTLV-1 associated inflammatory myopathies (HAIM) by studying muscle biopsy specimens and blood samples from 13 HAIM patients.

Results

Mean age of patients was 52.2 years. 7 patients suffered from polymyositis (PM), and 6, from inclusion body myositis (IBM). Histopathological changes were mild to moderate in most patients. Tumor necrosis factor (TNF)-alpha and myeloid dendritic cells were detected in several patients’ biopsies, and Human Leukocyte Antigen (HLA)-ABC, HLA-DR, and matrix metalloproteinase (MMP-2, -9), in most of them. Perforin was frequently detected but there were no apoptotic myonuclei. By means of in situ hybridization, we detected rare HTLV-1 infected infiltrating cells in the muscle tissue of 4 patients. The virus belonged to the cosmopolitan A subtype, transcontinental subgroup. Plasma anti-HTLV-1 antibodies titers were high, but the proviral load was not elevated when compared to asymptomatic HTLV-1 carriers. Myositis-associated autoantibodies were found in patients with HAIM as well as in HTLV-1 infected controls without HAIM, whereas IFN-gamma plasma levels were elevated in HAIM patients.

Conclusions

We describe 13 cases of HTLV-1 associated myositis, which show the classical anatomopathologic features of idiopathic myositis, with moderate muscle inflammation and atrophy. Proviral load was not elevated, but anti-HTLV-1 antiboides titer and IFN-gamma plasma levels were raised.

Copyright information

© Desdouits et al; licensee BioMed Central Ltd. 2011

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Authors and Affiliations

  • Marion Desdouits
    • 1
  • Olivier Cassar
    • 1
  • Thierry Maisonobe
    • 2
  • Alexandra Desrames
    • 1
  • Achille Aouba
    • 3
  • Olivier Hermine
    • 3
  • Jacqueline Mikol
    • 4
  • Marc Polivka
    • 4
  • Isabelle Penisson-Besnier
    • 5
  • Pascale Marcorelles
    • 6
  • Fabien Zagnoli
    • 7
  • Thomas Papo
    • 8
  • Arnaud Lacour
    • 9
  • Zahir Amoura
    • 2
  • Julien Haroche
    • 2
  • Patrick Chérin
    • 2
  • Antonio Texeira
    • 2
  • Anne-Sophie Morin
    • 10
  • Franck Mortreux
    • 11
  • Eric Wattel
    • 11
  • Michel Huerre
    • 12
  • Marie-Christine Cumont
    • 12
  • Huot Khun
    • 12
  • Sylviane Bassot
    • 1
  • Sandra Martin-Latil
    • 1
  • Graham Taylor
    • 13
  • Antoine Gessain
    • 1
  • Simona Ozden
    • 1
  • Pierre-Emmanuel Ceccaldi
    • 1
    • 14
  1. 1.Epidemiology and Physiopathology of Oncogenic Viruses UnitCNRS 3015, Pasteur InstituteParisFrance
  2. 2.Pitié Salpêtrière HospitalParisFrance
  3. 3.Necker HospitalParisFrance
  4. 4.Lariboisière HospitalParisFrance
  5. 5.University Hospital CenterAngersFrance
  6. 6.University Hospital CenterBrestFrance
  7. 7.Clermont Tonnerre Army HospitalBrestFrance
  8. 8.Bichat HospitalParisFrance
  9. 9.University Hospital CenterLilleFrance
  10. 10.Beaujon HospitalClichyFrance
  11. 11.Oncology and Biotherapies UnitLyon UniversityLyonFrance
  12. 12.Histotechnolgy and Histopathology UnitPasteur InstituteParisFrance
  13. 13.Faculty of MedicineImperial CollegeLondonUK
  14. 14.Paris 7 UniversityParisFrance

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