Retrovirology

, 5:O10 | Cite as

High prevalence of cytomegalovirus (CMV) infection in infants born to HIV infected mothers–ANRS French Perinatal Cohort (EPF)

  • Gaelle Guibert
  • Marianne Leruez-Ville
  • Christine Rouzioux
  • Roland Tubiana
  • Laurent Mandelbrot
  • Stéphane Blanche
  • Jean-Paul Teglas
  • Yassine BenMebarek
  • Jérôme Le Chenadec
  • Josiane Warszawski
  • ANRS French Perinatal Cohort (EPF)
Open Access
Oral presentation
  • 2.2k Downloads

Keywords

Sensorineural Hearing Sensorineural Hearing Loss Central Nervous System Disease Nervous System Disease Infected Mother 

Background

In developed countries, 0.3% to 0.5% of all newborns are congenitally infected by cytomegalovirus (CMV) with the risk of sensorineural hearing loss or mental retardation [1, 2]. Few results about congenital CMV infection in infants born to HIV-infected women have been reported [3]. Rate of disease progression and central nervous system disease was found to be higher in HIV-1-infected infants who acquire CMV infection in the first 18 months of life than those infected with HIV-1 alone [4]. We aimed to estimate the prevalence of neonatal CMV infection in children born to HIV-infected mothers between 1993 and 2004 enrolled in the ANRS French Perinatal Cohort (EPF).

Materials and methods

EPF is a national prospective multicenter cohort of mother-to-child HIV transmission. As part of the standardized follow-up of infants born alive between 1993 and 2004 in EPF sites, a urine sample was obtained within the ten first days of life. These samples were used to screen for congenital CMV infection, using rapid culture from 1993 to 2001 and real-time PCR since 2001.

Results

Between 1993 and 2004, 4995 of the 7878 newborns included in EPF were screened for CMV. The prevalence of CMV infection was 2.4% (119 positive tests; 95% confidence interval: 2.0–2.8). Thirteen of the 119 CMV infected newborns were also infected with HIV. The prevalence of CMV infection was higher in HIV-infected newborns (10.2%; 95% CI: 4.9-15.5) than in HIV-uninfected newborns (2.2%, 95% CI: 1.8-2.6, p<0.01).

Conclusions

The prevalence of congenital CMV infection was high in children born to HIV- infected mothers and was significantly higher in HIV-infected children than HIV-uninfected children.

Notes

Acknowledgements

The study was supported by the ANRS. We thank all cohort investigators and V Benhammou, N Chernai, A Diop, K Hamrene, P Huynh, C Laurent, M Peres, ERamos, L Boufassa, T Wack, N Zeller.

References

  1. 1.
    Barbi M, Binda S, Caroppo S, Calvario A, Germinario C, Bozzi A, et al: Multicity Italian study of congenital cytomegalovirus infection. Pediatr Infect Dis J. 2006, 25: 156-159. 10.1097/01.inf.0000199261.98769.29.CrossRefPubMedGoogle Scholar
  2. 2.
    Gratacap-Cavallier B, Morand P, Dutertre N, Bosson JL, Baccard-Longere M, Jouk PS, et al: Cytomegalovirus infection in pregnant women. Seroepidemiological prospective study in 1,018 women in Isere. J Gynecol Obstet Biol Reprod (Paris). 1998, 27: 161-166.Google Scholar
  3. 3.
    Doyle M, Atkins JT, Rivera-Matos IR: Congenital cytomegalovirus infection in infants infected with human immunodeficiency virus type 1. Pediatr Infect Dis J. 1996, 15: 1102-1106. 10.1097/00006454-199612000-00010.CrossRefPubMedGoogle Scholar
  4. 4.
    Kovacs A, Schluchter M, Easley K, Demmler G, Shearer W, La Russa P, et al: Cytomegalovirus infection and HIV-1 disease progression in infants born to HIV-1-infected women. Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection Study Group. N Engl J Med. 1999, 341: 77-84. 10.1056/NEJM199907083410203.PubMedCentralCrossRefPubMedGoogle Scholar

Copyright information

© Guibert et al.; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.

Authors and Affiliations

  • Gaelle Guibert
    • 1
  • Marianne Leruez-Ville
    • 2
    • 3
  • Christine Rouzioux
    • 2
    • 3
  • Roland Tubiana
    • 4
    • 5
  • Laurent Mandelbrot
    • 1
    • 6
    • 7
  • Stéphane Blanche
    • 3
    • 8
  • Jean-Paul Teglas
    • 1
    • 9
  • Yassine BenMebarek
    • 1
    • 10
  • Jérôme Le Chenadec
    • 1
    • 9
  • Josiane Warszawski
    • 1
    • 9
    • 10
    • 11
  • ANRS French Perinatal Cohort (EPF)
  1. 1.Inserm, U822Le Kremlin-BicêtreFrance
  2. 2.AP-HP, Virology DepartmentNecker HospitalParisFrance
  3. 3.EA 3620, Univ Paris Descartes 5ParisFrance
  4. 4.AP-HP, Department of infectious diseasesHôpital Pitié SalpêtrièreParisFrance
  5. 5.INSERM, U543ParisFrance
  6. 6.Univ Paris 7ParisFrance
  7. 7.AP-HP, Gynecology and obstetrics departmentHôpital Louis MourrierColombesFrance
  8. 8.AP-HP, Unité d'Immunologie Hématologie PédiatriqueNecker HospitalParisFrance
  9. 9.INEDParisFrance
  10. 10.AP-HP, Epidemiology departmentHopital BicêtreLe Kremlin-BicêtreFrance
  11. 11.Univ Paris-Sud, Faculté de Médecine Paris-SudLe Kremlin-BicêtreFrance

Personalised recommendations