Retrovirology

, 3:S20 | Cite as

Virus-specific cellular immune correlates of survival in vaccinated monkeys after SIV challenge

  • Norman Letvin
Open Access
Oral presentation

Keywords

Virus Infection Rhesus Monkey Primary Role Prolonged Survival Clinical Progression 

Understanding the characteristics of the virus-specific T lymphocyte response that will confer optimal protection against the clinical progression of AIDS will inform the development of an effective cellular immune-based HIV vaccine. We have recently shown that survival in plasmid DNA-primed/recombinant adenovirus-boosted rhesus monkeys that are challenged with SIVmac251 is associated with the preservation post-challenge of central memory CD4+ T lymphocytes and robust IFN-g-producing SIV-specific CD8+ and CD4+ T lymphocyte responses. Further studies were initiated to extend these observations to determine which virus-specific T lymphocyte subpopulations play a primary role in controlling disease progression and characterize the functional repertoire of these cells. We show that the preservation of the SIV-specific central memory CD8+ T lymphocyte population and a linked SIV-specific CD4+ T lymphocyte response are associated with prolonged survival in vaccinated monkeys following challenge. Further, we demonstrate that SIV-specific IFN-g, TNF-a, and IL-2 producing T lymphocytes are all comparably associated with protection against disease progression. These findings underscore the contribution of virus-specific central memory T lymphocytes in controlling clinical progression in vaccinated individuals following a primate immunodeficiency virus infection.

Copyright information

© Letvin; licensee BioMed Central Ltd. 2006

This article is published under license to BioMed Central Ltd.

Authors and Affiliations

  • Norman Letvin
    • 1
  1. 1.Chief, Division of Viral PathogenesisBeth Israel Deaconess Medical CenterBostonUSA

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