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Retrovirology

, 2:S96 | Cite as

Use of the Synthetic Copolymer PSMA as a Component in a Combination Microbicide Active Against HIV-1

  • Jin Qian
  • Shendra Miller
  • Mary L Ferguson
  • Lori Schlipf
  • Mohamed E Labib
  • Robert F Rando
  • Brian Wigdahl
  • Fred C Krebs
Open Access
Oral presentation

Keywords

Human Immunodeficiency Virus Polyethylene Active Ingredient Optimal Combination Virus Type 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

The remarkable successes achieved using combination therapy to treat systemic human immunodeficiency virus type 1 (HIV-1) infection suggest that combination microbicides, which include two or more active ingredients, may also provide a particularly effective means to prevent HIV-1 transmission. We have recently identified the compound PSMA, an alternating copolymer of polystyrene (PS) and maleic anhydride (MA), as a potential partner for our candidate microbicide polyethylene hexamethylene biguanide (PEHMB), a member of the polybiguanide family of compounds. In vitro studies of PSMA demonstrated that this compound is minimally cytotoxic and highly effective against both macrophage- and T cell-tropic strains of HIV-1. We hypothesize that the dissimilar mechanisms of action of PSMA and PEHMB may provide additive or synergistic activity against HIV-1. Experiments are now underway to identify optimal combinations of PSMA and PEHMB to be used in experiments to assess toxicity, anti-HIV-1 activity, and formulation strategies. These investigations will be used to confidently advance the preclinical development of PSMA and a combination microbicide containing both compounds toward human trials.

Copyright information

© The Author(s) 2005

Authors and Affiliations

  • Jin Qian
    • 1
  • Shendra Miller
    • 1
  • Mary L Ferguson
    • 1
  • Lori Schlipf
    • 1
  • Mohamed E Labib
    • 2
  • Robert F Rando
    • 2
  • Brian Wigdahl
    • 1
  • Fred C Krebs
    • 1
  1. 1.Department of Microbiology and Immunology, and Institute for Molecular Medicine and Infectious DiseaseDrexel University College of MedicinePhiladelphiaUSA
  2. 2.Novaflux Biosciences, Inc.PrincetonUSA

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