Retrovirology

, 2:S151 | Cite as

yesHIV Impairs Reverse Cholesterol Transport from Macrophages: A Possible Mechanism of Atherogenic Effect of HIV-1 Infection

  • Zahedi Mujawar
  • Honor Rose
  • Matthew P Morrow
  • Jan Orenstein
  • Yuri Bobryshev
  • Dmitri Sviridov
  • Michael Bukrinsky
Open Access
Oral presentation
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Keywords

Cholesterol Coronary Artery Disease Atherosclerotic Plaque Foam Cell Cholesterol Efflux 

Both asymptomatic HIV-1 infection and AIDS are consistently associated with increased risk of coronary artery disease (CAD). The accumulation of cholesterol-loaded 'foam cells' (macrophages) in the walls of arteries is a characteristic feature of atherosclerosis. Here we demonstrate that HIV-1 infection of macrophages leads to impairment of apoA-I-dependent cholesterol efflux, accumulation of cholesterol and formation of foam cells. This effect is mediated by the HIV-1 protein Nef. Transfection of RAW cells with the Nef-expressing plasmid resulted in reduction of efflux and cholesterol accumulation. Nef impaired activity of ABCA1, the main transporter of cholesterol to apoA-I. The role of HIV-infected macrophages in atherosclerosis was supported by the presence of HIV-positive foam cells in atherosclerotic plaques of HIV-infected patients. These results suggest a mechanism by which HIV-infected macrophages may contribute to atherosclerotic plaque formation.

Copyright information

© The Author(s) 2005

Authors and Affiliations

  • Zahedi Mujawar
    • 1
  • Honor Rose
    • 2
  • Matthew P Morrow
    • 1
  • Jan Orenstein
    • 1
  • Yuri Bobryshev
    • 3
  • Dmitri Sviridov
    • 2
  • Michael Bukrinsky
    • 1
  1. 1.Department of Microbiology & Tropical MedicineThe George Washington UniversityWashingtonUSA
  2. 2.Baker Heart Research InstituteMelbourneAustralia
  3. 3.University of New South WalesSydneyAustralia

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