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Retrovirology

, 2:P130 | Cite as

Association Between the Presence of CCR5-specific Antibodies and Long Term Non Progression

  • Lucia Lo palco
  • Claudia Pastori
  • Caterina Uberti-Foppa
  • Guido Poli
  • Greta Taskaris
  • Chiara Alberti
  • Adriano Lazzarin
  • Renato Longhi
Open Access
Poster presentation
  • 735 Downloads

Keywords

Infectious Disease Cancer Research Vaccine Design Seronegative Donor Uninfected Subject 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Most transmitted HIV-1 strains use CCR5 as coreceptor. Antibodies (Abs) to CCR5 have been detected in highly exposed to HIV-1 but uninfected subjects, thus they could be involved in HIV protection. To assess whether these Abs may also contribute to slow HIV-disease progression, we searched for anti-CCR5 Abs in 499 subjects, including 87 Long Term Non Progressors (LTNP), 70 Progressors, 135 HIV+ HAART treated, and 207 seronegative donors. We found anti-CCR5 Abs in a fraction of LTNP (22.9%), but not in the other populations studied (p < 0.0001). These Abs efficiently prevent infection of HIV-R5 strains representing subtypes B, C and A by inducing a stable and long last down regulation of CCR5 on surface of T lymphocytes. Follow-up studies showed that the loss of anti-CCR5 Abs, occurred in some subjects, was significantly associated with a progression toward disease. Thus, the anti-CCR5 Abs could be relevant to vaccine design and therapeutics.

Copyright information

© The Author(s) 2005

Authors and Affiliations

  • Lucia Lo palco
    • 1
    • 2
  • Claudia Pastori
    • 1
  • Caterina Uberti-Foppa
    • 1
  • Guido Poli
    • 1
  • Greta Taskaris
    • 1
  • Chiara Alberti
    • 1
  • Adriano Lazzarin
    • 1
  • Renato Longhi
    • 1
  1. 1.Immunology and Infectious Disease DepSan Raffaele Scientific InstituteMilanoItaly
  2. 2.Duke University Medical Center, SORF BldgDurhamUSA

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