Retrovirology

, 11:P66 | Cite as

Impairment of humoral and cellular immune response to tetanus toxoid in HTLV-1 infected individuals

  • Anselmo S Souza
  • Camila F Amorim
  • Natália Carvalho
  • Silvane B Santos
  • Edgar M Carvalho
Open Access
Poster presentation

Keywords

Healthy Subject Peripheral Blood Mononuclear Cell Antigen Present Cell Tetanus Infected Individual 

The human T cell lymphotropic virus type-1 (HTLV-1) infect mainly T cells, dendritic cells and macrophages inducing T cell proliferation and increasing production of chemokines and cytokines by peripheral blood mononuclear cells (PBMC). However, as HTVL-1 may modify the immune response to other infectious agents, the aim of this study was to evaluate the humoral and cellular immune response before and after vaccination with tetanus toxoid (TT). Participants included 14 HTLV-1 carriers and 12 healthy subjects (HS). These individuals were immunized with two doses of tetanus toxoid vaccine. Antibodies to TT were determined by ELISA and the frequency of T cells expressing cytokines as well as the frequency of monocytes expressing co-stimulatory molecules were determined by FACS. The IgG titers anti-TT increased after immunization in both groups (p = 0.001), but HTLV-1 patients had lower levels of IgG anti-TT after immunization when compared with HS (p = 0.007). The frequency of CD4+ T cells expressing IFN-g, TNF and IL-10, after stimulation with TT, was lower in HTLV-1 infected subjects than the HS after immunization (p < 0.05). TNF and IL-12 expression by monocytes after stimulation with TT were higher in the HTLV-1 group than in HS. However there was an impairment in the HLA-DR expression by monocytes from HTLV-1 infected subjects. These results indicate that HTLV-1 infected subjects have a decreasing in humoral response and an impairment in both antigen presenting cells and T cell functions to a biased antigen. Financial Support: INCT-DT, CNPq, NIH R01.

Copyright information

© Souza et al; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Authors and Affiliations

  • Anselmo S Souza
    • 1
    • 2
  • Camila F Amorim
    • 1
  • Natália Carvalho
    • 1
  • Silvane B Santos
    • 1
    • 2
    • 3
  • Edgar M Carvalho
    • 1
    • 2
  1. 1.Immunology ServiceFederal University of BahiaSalvador, BahiaBrazil
  2. 2.Natiotal Institute of Science and Technology - Tropical DiseasesSalvador, BahiaBrazil
  3. 3.Institute of Biological ScienceState University of Feira de SantanaFeira de Santana, BahiaBrazil

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