Outcome of diagnostic intervention predicts health-related quality of life scores among children with food allergy
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KeywordsLinear Model Negative Impact Clinic Setting Repeated Measure General Linear Model
Access to diagnostic care, regardless of diagnostic outcome, may attenuate the negative impact of food allergy on health-related quality of life (HRQL). We sought to determine if improved HRQL can be demonstrated among children, 0-12 years, who receive diagnostic care for food allergy in an allergy clinic setting.
Parents attending clinic with their child completed the Food Allergy Quality of Life Questionnaire Parent Form before and after their visit. Parents with children on the clinic waitlist served as controls. HRQL scores were analyzed according to visit outcome: fewer or same number of food allergies. A sub-analysis of scores among children who underwent an oral food challenge (OFC) was conducted. The General Linear Model for Repeated Measures was used to compare changes in score over time between outcomes, and to test for interaction between score changes and outcomes.
Mean pre-/post-visit scores were 1.93/1.68 for fewer (n = 64), 2.37/2.37 for same (n = 36), and 1.70/1.79 for controls (n = 59). Interaction between score change and visit outcome was significant (F 3.355, p = 0.037). Pre-/post-visit scores for OFC outcomes only were 2.24/2.03 for fewer (n = 35) and 2.03/2.53 for same (n = 10) number of food allergies. Interaction between score change and OFC outcome was significant (F 5.518, p = 0.023).
Improvement in HRQL associated with food allergy diagnostic care appears to be dependent on visit outcome. Diagnosis of fewer food allergies predicted improvement in HRQL scores among children; this improvement may be most pronounced among those who receive oral food challenges.
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