Vitamin D levels in peanut allergic children
KeywordsPublic Health Confidence Interval Body Mass Index Linear Modeling Generalize Linear Modeling
The prevalence of peanut allergy is increasing. The reasons for this are not entirely known. A factor may be vitamin D (Vit D).
This study was performed in a referral allergist’s office in Ontario. Prospectively, all patients (<18 years old) with peanut allergy who were tested for peanut specific IgE (PN IgE) also had Vit D measured. All measurements were done between December 2010 and May 2011. The Vit D measure was 25-hydroxy vitamin D. Patients were divided into three groups: deficient (less than 25 nmol/L), insufficient (25-75 nmol/L) and sufficient (75-250 nmol/L). Vit D levels were compared to PN IgE, sex, age, body mass index (BMI) and other allergies.
Fifty peanut allergic patients were included. The mean Vit D level of the patients was 73.8 nmol/L and the 95% confidence interval was 69.6 - 75.7 nmol/L. One patient (2%) had deficient and thirty-one (62%) of the patients had insufficient Vit D levels. Nineteen (38%) had Vit D levels in the sufficient range. There was no correlation between Vit D levels and PN IgE or BMI. Generalized linear modeling showed that vit D levels were predicted by age and sex (p=0.04 & p=0.002, respectively).
Two percent of our patients had deficient Vit D levels while 62% of our patients had insufficient Vit D levels. These levels were statistically associated with age and sex. Insufficiency of Vit D may play a role in peanut allergy.
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