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Association of fat mass and obesity-associated gene rs9939609 variant with early onset obesity among bataknese and Chinese children in Indonesia

  • Siska Mayasari Lubis
  • Jose Batubara
  • Harun Alrasyid Damanik
  • Miswar Fattah
Open Access
Poster presentation
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Keywords

Obesity Waist Circumference Case Control Study Elementary School Anthropometric Measurement 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Background

Obesity is becoming a worldwide epidemic in modern society, it is prevalent in individuals of both genders and of all ages, socio-economic strata, and ethnic group. Several studies have reported an association between rs9939609 polymorphisms of the FTO gene and obesity. However, this association has not yet been studied among the Indonesian children.

Aims

This is the first study in Indonesia to investigate the association between fat mass and obesity-associated gene rs9939609 variant with early onset obesity among Bataknese (n=94) and Chinese (n=66) children in Medan, North Sumatera, Indonesia.

Methods

We conducted a case control study in ten elementary schools in Medan, North Sumatera, Indonesia. Case group (n=105) were children with early onset obesity and control group (n=55) were normal weight children. The inclusion criteria were Bataknese and Chinese children, aged 6-12 years with early onset obesity. We examined body weight and height, body mass index, waist circumference. Genotyping was performed using a TaqMan assay for rs9939609 polymorphism.

Results

A total of 160 children between 6 and 12 years old were recruited in this study. The distribution of genotypes and alleles was significantly different among ethnicities (P=0,004), but no association was found for early onset obesity, related anthropometric measurements and gender. FTO rs9939609 allele was not associated with central obesity.

Conclusion

Our study showed there were no associations between fat mass and obesity-associated gene rs9939609 variant with early onset obesity. However, the prevalence of genotypes for FTO rs9939609 in our study were similar with other study in China and Malaysia.

Copyright information

© Lubis et al; licensee BioMed Central Ltd. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Authors and Affiliations

  • Siska Mayasari Lubis
    • 1
  • Jose Batubara
    • 2
  • Harun Alrasyid Damanik
    • 3
  • Miswar Fattah
    • 4
  1. 1.Pediatric Endocrinology Division, Child Health Department Medical SchoolUniversity of Sumatera Utara, H.Adam Malik General HospitalMedan, Sumatera UtaraIndonesia
  2. 2.Pediatric Endocrinology Division, Child Health Department Medical SchoolUniversity of Indonesia, Cipto Mangunkusumo General HospitalJakartaIndonesia
  3. 3.Department of Nutritional Sciences, Medical SchoolUniversity of Sumatera UtaraMedan, Sumatera UtaraIndonesia
  4. 4.Department of Molecular BiologyProdia Widyahusada LaboratoryJakartaIndonesia

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