Pediatric Rheumatology

, 6:P74 | Cite as

Clinical significance of anti-cyclic citrullinated peptide antibodies in patients with juvenile rheumatoid arthritis

  • Li Bo
  • Ye Zhizho
  • Guo Fenlia
  • Li Jianso
Open Access
Poster presentation
  • 1.2k Downloads

Keywords

Public Health Peptide Rheumatoid Arthritis Arthritis Clinical Significance 

Background

Anti-cyclic citrullinated peptide antibodies (anti-CCP Abs) are considered to be specific for rheumatoid arthritis (RA), but there are few data on anti-CCP Abs and its relationship with the disease activity in patients with juvenile rheumatoid arthritis (JRA). The aim of this study was to explore the sensitivity and specificity of anti-CCP Abs in JRA.

Materials and methods

Serum samples obtained from 37 JRA patients (33 girls and 4 boys, with a mean age of 12.31 ± 3.29 years) and 20 healthy controls (matched for age and sex ratio with JRA patients) were assayed for anti-CCP Abs using ELISA method. The relationship between anti-CCP Abs and disease activity were also analyzed.

Results

Prevalence of anti-CCP Abs was 8.1% (3/37) in JRA patients. In 20 normal subjects, no one was found anti-CCP Abs positive. The sensitivity of anti-CCP Abs was 8.1%, the specificity was 100%. Disease activity score (DAS28) showed no significant difference between anti-CCP Abs-positive group and anti-CCP Abs-negative group.

Conclusion

Prevalence of anti-CCP Abs was very low in patients with JIA. It was not very helpful for diagnosis of JIA and estimating its disease activity. Therefore it is not necessary for anti-CCP Abs be tested routinely in patients with JIA.

Copyright information

© Bo et al; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.

Authors and Affiliations

  • Li Bo
    • 1
  • Ye Zhizho
    • 1
  • Guo Fenlia
    • 1
  • Li Jianso
    • 1
  1. 1.Department of RheumatologyXiangmihu Branch of Shenzhen Fourth People's HospitalShenzhenPR China

Personalised recommendations