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Pediatric Rheumatology

, 6:P104 | Cite as

Performance of different sets of criteria for clinical response evaluation in a non-selected cohort of juvenile idiopathic arthritis (JIA) patients

  • R Gutiérrez-Suárez
  • R Burgos-Vargas
Open Access
Poster presentation
  • 663 Downloads

Keywords

Gold Arthritis Receiver Operating Characteristic Gold Standard Likelihood Ratio 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Objective

To compare the performance of 4 sets of criteria for clinical response evaluation in JIA patients.

Methods

An observational study of a non-selected cohort of JIA patients in the out-patient clinic was conducted. Four sets of criteria: DAS, DAS28, CDAI and SDAI were evaluated and compared with the ACR-Ped-30 and the clinician judgment of response (CJR) (100 mm-VAS) as the gold standard to evaluate clinical response in JIA patients. Performance was assessed by the receiver operating characteristic (ROC) curve analysis and other statistics for diagnostic tests.

Results

50 JIA patients (female/male ratio: 1.2:1; mean age at diagnosis: 6.4 ± 3.3 years; mean disease duration: 5.3 ± 2.7 years) were evaluated. The area under the ROC curve (AUC) with 95% confidence interval (95%CI), the likelihood ratio (LR) with 95%CI, the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were: 0.842 (0.691–0.994); 6.48 (1.03–40.75); 80.9; 87.5; 97.1; and 46.6; respectively for the CJR in comparison with the ACR-Ped-30 as gold standard; and of 0.700 (0.532–0.868); 2.00 (1.05–3.80); 80.0; 60.0; 82.3 56.2; respectively for the DAS28; 0.752 (0.599–0.906); 2.89 (1.23–6.83); 77.1; 73.3; 87.1 57.8; respectively for the SDAI; and 0.705 (0.542–0.868); 2.23 (1.06–4.68); 74.2; 66.6 83.8; 52.6; respectively for the CDAI, when compared with the CJR. The performance of the four sets of criteria in comparison with the ACR-Ped-30 was poor.

Conclusion

In the daily clinical practice the DAS 28, SDAI and CDAI can be used for the evaluation of clinical response in JIA patients.

Copyright information

© Gutiérrez-Suárez and Burgos-Vargas; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.

Authors and Affiliations

  • R Gutiérrez-Suárez
    • 1
    • 2
  • R Burgos-Vargas
    • 1
  1. 1.Hospital General de MéxicoMéxicoMexico
  2. 2.Hospital Shriners para niños. A.C.MéxicoMexico

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