PReS-FINAL-2071: Anti-type II collagen antibodies, anti-CCP, IgA-RF and IgM-RF are associated with joint damage eight years after onset of juvenile idiopathic arthritis (JIA)
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KeywordsPublic Health Collagen Arthritis Serum Sample Median Time
Antibodies specific for native human type II collagen (anti-CII) characterize an early inflammatory/destructive phenotype in adults with RA. There are no data presented so far on this antibody and its possible influence on disease course/outcome in children with JIA.
We wanted to relate occurrence of anti-CII, IgM-RF, IgA-RF and anti-CCP to assessment of joint damage, outcome and ILAR categories after eight years of disease in children with JIA.
From the Nordic JIA database 192 patients with available sera were included. Serum samples were collected at a median time of 4 months (IQR 2-7) after disease onset. Patients were followed prospectively for a median of 97 months (IQR 95-105). At the 8-year follow-up visit, data on remission according to the preliminary criteria of C. Wallace et al as well as joint damage according to JADI were collected. Frozen and stored sera were analyzed with enzyme immunoassays for anti-CII, IgM-RF, IgA-RF and anti-CCP. Reference values for adults were used.
Anti-type II collagen antibodies occurred in 3.1% of patients sera, IgM-RF in 3.6%, IgA-RF in 3.1%, anti-CCP in 2.6% of the patients. Occurrence of RF and anti-CCP did to some extent overlap, but rarely with anti-CII. The polyarticular and oligoarticular extended categories were overrepresented in patients with any of the four autoantibodies. All four autoantibodies were significantly associated with joint damage after eight years, but we found no association with ongoing disease activity after eight years.
- Occurrence of anti-CII did rarely overlap with anti-CCP, IgA-RF and IgM-RF, but all four were associated with joint damage after 8 years of disease in patients with JIA.
- Further studies on anti-CII in patients with JIA are needed.
Disclosure of interest
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.