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Pediatric Rheumatology

, 11:A9 | Cite as

P01-005 – Idiopathic uveitis and FMF

  • F Salehzadeh
  • O Yasrebi
  • S Jahangiri
  • S Hosseiniasl
Open Access
Meeting abstract
  • 769 Downloads

Keywords

Rheumatoid Arthritis Arthritis Genetic Analysis Uveitis Familial Mediterranean Fever 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Introduction

Familial Mediterranean fever (FMF) is an auto inflammatory disease characterized by attacks of fever and polyserositis. FMF is often associated with other autoimmune diseases such as rheumatoid arthritis, PAN, Behcet.

Objectives

Uveitis is an inflammatory process of eyes caused by underlying infectious and inflammatory disorders. This study investigates the probable relationship between Idiopathic Uveitis and familial Mediterranean fever.

Methods

Patients with idiopathic uveitis that didn't have Infectious and inflammatory causes referred to the genetic laboratory to12 common MEFV genes analysis. P369S, F479L, M680I(G/C), M680I(G/A), I692del, M694V, M694I, K695R, V726A, A744S, R761H, E148Q mutations were analysed by using amplification refractory system for 11 of those and the PCR was performed for E148Q.

Results

12 patients with idiopathic uveitis were enrolled in this study. 10 of them were female and 2 were male. The youngest patient was a 7-year-old child and the oldest was 57. The most common complaints of patients was blurred vision and then eye redness. One patient was heterozygous for Wt/R761H in the MEFV genetic analyses. Genetic analysis of 12 most common MEFV mutations in the patients with idiopathic uveitis didn't have any positive results.

Conclusion

According to the analysis of 12 most common MEFV gene mutations, FMF is not an underlying cause of idiopathic uveitis. On the other hand uveitis merely could not be the first presentation of FMF.

Disclosure of interest

None declared

Copyright information

© Salehzadeh et al; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Authors and Affiliations

  • F Salehzadeh
    • 1
    • 2
  • O Yasrebi
    • 2
  • S Jahangiri
    • 1
  • S Hosseiniasl
    • 3
  1. 1.Pediatric RheumatologyBouali HospitalIran, Islamic Republic Of
  2. 2.Pediatric RheumatologyArumsIran, Islamic Republic Of
  3. 3.GeneticEmam Khomeini hospitalArdabilIran, Islamic Republic Of

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