Systolic T1 mapping for estimation of myocardial diffuse fibrosis
KeywordsPlot Figure Diffuse Fibrosis Myocardial Diffuse Fibrosis Myocardial Thickness Histological Validation
Parametric T1 mapping currently allows non-invasive estimation of diffuse left-ventricular fibrosis. Imaging for T1 mapping is usually acquired during the diastolic phase. However, in tachycardia and arrhythmia, diastasis is short and imaging challenging. Conversely, systolic T1 mapping might offer an advantage and further enable more accurate ROI delineation for T1 maps as the myocardium is thicker. Although motion is also more likely during image generation. Recent studies using various T1 mapping sequences in systole have usually shown small differences (~1-2%) between systolic and diastolic T1 values [1, 2, 3, 4] but older studies had shown larger differences . We investigated the difference between systolic and diastolic T1 mapping using Siemens investigational prototype 448B.
10 healthy volunteers (average age 29 ± 6 yrs, 5 male) underwent CMR on a 1.5T scanner (MAGNETOM Avanto, Siemens Healthcare, Germany). Diastolic native T1 maps were taken after manually identifying diastasis from the short-axis cine (SAX) and calculating the diastolic trigger delay (DTD) for each person. Systolic native T1 mapping was undertaken subsequently by manually identifying peak systole from SAX and calculating the systolic trigger delay (STD). Each patient had 4 native T1 maps (2 basal and 2 mid level) to enable intra-study reproducibility assessment. These values were used to obtain an average basal and a separate average mid-level T1 value as well as an average of all four values to estimate global T1. We also calculated the impact of timing on the native-blood T1 as potentially needed for ECV calculation.
Systolic T1 mapping is reproducible in volunteers, with small differences between systole and diastole. This may be of particular interest in patients with arrhythmia, tachycardia or thin myocardium. Further histological validation studies in patients with arrhythmia are indicated, particularly comparing systolic T1 mapping with the arrhythmia-insensitive rapid (AIR) cardiac T1-mapping pulse sequence .
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