Spiral imaging with off-resonance reconstruction for MRI-guided cardiovascular catheterizations using commercial off-the-shelf nitinol guidewires
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KeywordsSpiral Imaging Spiral Sequence bSSFP Sequence Anatomical Imaging Data Nitinol Guidewires
MRI-guidance of cardiovascular catheterization offers improved soft-tissue contrast and reduced ionizing radiation exposure. The application of MRI-guidance to complex catheterization procedures has been limited by the unavailability of guidewires that are safe and visible under MRI. Here, we use RF-efficient spiral imaging for MR-guided cardiovascular catheterization, with real-time off-resonance reconstruction for improved visualization of off-the-shelf nitinol guidewires.
MRI-guided left and right heart catheterizations were performed on a swine using a commercial nitinol guidewire (0.035"/145 cm Nitrex, Covidien, Plymouth, MN) and balloon-tipped catheter (7 Fr, Arrow-Teleflex, Limerick, PA) with spiral imaging (gradient echo, 16 interleaves, TE/TR =0.86/11 ms, flip = 10°, FOV = 300 mm x 300 mm, matrix = 192 x 192, slice thickness = 6 mm). To enhance guidewire visualization, we exploited the off-resonance signal near the guidewire. Using a custom reconstruction framework (Gadgetron ), the imaging data was reconstructed at two different off-resonance frequencies (± 100 Hz) and the images were subtracted to produce guidewire-enhanced images. The method was implemented such that operators could rapidly toggle between anatomical imaging, saturation pre-pulses for visualization of gadolinium-filled balloon  and guidewire-enhanced imaging, as-needed throughout the procedure.
RF-induced heating of the guidewire/catheter configuration was evaluated in an ASTM 2182 phantom. A fiber-optic temperature probe (0.007" OpSens, Quebec, Canada) affixed to the guidewire tip measured temperature during 2 minutes of continuous scanning with the spiral sequence and our standard real-time imaging sequence (Cartesian bSSFP, TE/TR = 1.31/2.62 ms, flip angle = 45°).
This visualization method is particularly flexible because it uses a targeted reconstruction of standard anatomical imaging data. This method may enable safe MRI-guided cardiovascular catheterizations using commercially available nitinol guidewires.
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