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Subclinical cardiac abnormalities and physical function in asymptomatic elderly

  • Angela S Koh
  • Feiqiong Huang
  • Thu Thao Le
  • Jia ing Wong
  • Ru San Tan
  • Serene Chua
  • Yi Ying Han
  • Stuart Cook
  • Woon Puay Koh
Poster presentation
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Keywords

Extremity Function Left Ventricular Ejection Fraction Physical Function Cardiac Index Left Ventricular Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Background

While it is known that the heart remodels progressively with age, data characterizing the relationship between cardiac remodelling and function on physical function among the aged are limited.

Aim

We investigated the association between left ventricular (LV) concentricity and LV function with handgrip strength (shown to correlate with mortality in the elderly) and timed-up-and-go test (for lower extremity function) among clinically asymptomatic elderly.

Methods

In this community-based cohort of 28 patients free of known cardiac disease (mean age 73.8 ± 4) with preserved LV ejection fraction (mean LVEF 69.8 ± 6.4) and cardiac index (mean 3.1 ± 0.57), we assessed cardiac remodelling by cardiac MRI (concentricity0.67 (mass/end-diastolic volume0.67) and LV function by resting tissue Doppler imaging (TDI) performed at the septal and lateral mitral annulus, deriving myocardial systolic velocity (S), diastolic velocity (E) and ratio of E/A.

Results

There were significant correlations between handgrip and LV concentricity (r = 0.49, p = 0.008), lateral S (r = 0.45, p = 0.041), septal A (r = 0.45, p = 0.04), and between timed-up-and-go and LV concentricity (r = 0.47, p = 0.013), lateral E/A (r=-0.49, p = 0.023), septal A (r = 0.45, p = 0.043). By regression analysis, LV concentricity (β=0.071, 95%CI 0.011-0.132, p = 0.023) (with adjustment for systolic blood pressure) and lateral E/A (β=-0.15, 95%CI -0.29—0.009, p = 0.039) were independently predictive of handgrip strength and timed-up-and-go respectively.

Conclusions

These preliminary observations provide important insights into a possible link between subclinical alterations in cardiac structure and function and physical function, further study is required to clarify these findings with a view to preserve health and function amongst the elderly.

Copyright information

© Koh et al. 2016

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Authors and Affiliations

  • Angela S Koh
    • 1
    • 2
  • Feiqiong Huang
    • 1
  • Thu Thao Le
    • 1
  • Jia ing Wong
    • 1
  • Ru San Tan
    • 1
    • 2
  • Serene Chua
    • 1
  • Yi Ying Han
    • 1
  • Stuart Cook
    • 1
    • 2
  • Woon Puay Koh
    • 2
  1. 1.Cardiology, National Heart Centre SingaporeSingaporeSingapore
  2. 2.Duke-NUS Graduate Medical SchoolSingaporeSingapore

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