Biomarkers of hemodynamic stress and aortic stiffness post-STEMI: a cross-sectional analysis

  • Sebastian J Reinstadler
  • Hans-Josef Feistritzer
  • Gert Klug
  • Luc Huybrechts
  • Angelika Hammerer-Lercher
  • Johannes M Mair
  • Wolfgang-Michael Franz
  • Bernhard Metzler
Open Access
Poster presentation
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Keywords

Cardiovascular Magnetic Resonance Natriuretic Peptide Pulse Wave Pulse Wave Velocity Multiple Linear Regression Analysis 

Background

We aimed to evaluate the association between biomarkers of hemodynamic stress and aortic stiffness assessed at a chronic stage after ST-segment elevation myocardial infarction (STEMI).

Methods

Fifty-four patients four months after acute STEMI were enrolled in this cross-sectional, single-center study. N-terminal pro B-type natriuretic peptide (NT-proBNP), mid-regional pro-A-type natriuretic peptide (MR-proANP) and mid-regional pro-adrenomedullin (MR-proADM) levels were measured by established assays. Aortic stiffness was assessed by the measurement of pulse wave velocity using velocity-encoding, phase-contrast cardiovascular magnetic resonance imaging.

Results

NT-proBNP, MR-proANP and MR-proADM concentrations were all correlated with aortic stiffness in univariate analysis (r = 0.378, r = 0.425, r = 0.532, all p < 0.005, respectively). In multiple linear regression analysis, NT-proBNP (ß = 0.316, p = 0.005) and MR-proADM (ß = 0.284, p < 0.020) levels were associated with increased aortic stiffness independently of age, blood pressure and renal function. In receiver operating characteristic analysis, NT-proBNP was the strongest predictor for high aortic stiffness (area under the curve: 0.82, 95% CI 0.67 - 0.96).

Conclusions

At a chronic stage after STEMI, concentrations of biomarkers for hemodynamic stress, especially NT-proBNP, are positively correlated with aortic stiffness. These biomarkers might also be useful as predictors of high aortic stiffness post-STEMI.

Funding

Austrian Society of Cardiology.

Copyright information

© Reinstadler et al; licensee BioMed Central Ltd. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Authors and Affiliations

  • Sebastian J Reinstadler
    • 1
  • Hans-Josef Feistritzer
    • 1
  • Gert Klug
    • 1
  • Luc Huybrechts
    • 1
  • Angelika Hammerer-Lercher
    • 2
  • Johannes M Mair
    • 1
  • Wolfgang-Michael Franz
    • 1
  • Bernhard Metzler
    • 1
  1. 1.University Clinic of Internal Medicine III, Cardiology and AngiologyMedical University InnsbruckInnsbruckAustria
  2. 2.Central Institute for Medical Laboratory DiagnosticsMedical University of InnsbruckInnsbruckAustria

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