Free-breathing 3D cardiac function with accelerated magnetization transfer prepared imaging
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KeywordsMagnetization Transfer Soft Thresholding Isotropic Spatial Resolution Phantom Scan Cardiac Time
3D cardiac MRI has long held promise for improved heart coverage, higher resolution, and reduced sensitivity to poor breath-hold reproducibility. However, its use has been limited by reduced blood pool to myocardium contrast for spoiled and balanced steady-state free precession (bSSFP) implementations. T2-preparation techniques  are capable of increasing contrast but are unfortunately limited by lengthy preparation periods and resulting scan inefficiencies. In this work, we develop a paradigm for high contrast 3D cardiac function that relies on the alternative use of magnetization transfer (MT) preparation  combined with accelerated 3D spoiled gradient echo imaging (SPGR).
An off-resonance RF pulse was interleaved with whole-heart, respiratory gated 3D radial SPGR sampling . Simulations and phantom scans were performed to optimize MT saturation (power, off-resonance, and frequency). Phantom scans utilized 4% agar, fat, and doped water. After optimization, initial volunteer images were collected on a clinical 1.5T system (HDx, GE, Waukesha, WI) using: FOV = 64 × 32 × 32 cm3, 2.0 mm isotropic spatial resolution, TR/TE1/TE2 = 5.6/1.32/3.32 ms, α = 4°, free-breathing: scan time = 10 min, 50% acceptance window (bellows), number of projections = 39,000. In-vivo experiments utilized a 1600°, 20 ms Hamming-windowed Sinc pulse applied every 10 TRs. This pulse was applied at 210 Hz off-resonance providing some fat-saturation. In addition, two full echoes (TE1 and TE2) at ± 62.5 kHz were added to further remove fat signal while increasing SNR of water images. Twenty cardiac time frames were reconstructed using iterative soft thresholding of temporal differences with a spatial wavelet transform.
The feasibility of a novel whole-heart functional cardiac acquisition using MT preparation with isotropic spatial resolution in a clinically reasonable scan time is presented. Further studies on optimization of acquisition parameters, including off-resonance frequency, number of projections, and acquired spatial resolution, will improve the applicability of the sequence for clinical situations.
NIH grant 2R01HL072260.
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