Mitral valve stenosis and left ventricular hemodynamic alterations after mitral valve repair
KeywordsMitral Valve Mitral Valve Stenosis Mitral Valve Repair Ischemic Mitral Regurgitation Diastolic Inflow
Mitral valve repair (MVR) shows clinical and economic superiority over mitral valve replacement in patients with dystrophic and rheumatic regurgitation, but outcomes are less certain in chronic ischemic mitral regurgitation (IMR). We hypothesize that MVR may have adverse effects on LV hemodynamics resulting from suboptimal annuloplasty geometry and post-repair mitral valve stenosis whose consequences are most acutely felt in IMR patients because of their impaired LV function. To test this hypothesis, we qualitatively described post-repair hemodynamics and measured LV inflow quantities (peak diastolic inflow velocity, transmitral pressure, and inflow angle) after MVR in sheep.
The University of Pennsylvania IACUC approved all experiments. Dorsett swine (n = 7) were anesthetized, underwent baseline MRI and echocardiography followed by MVR with varying annuloplasty size and shape (24, 26, 30 and 32 mm Carpentier-Edwards Physio; Edwards Lifesciences, 30 mm Duran Ancore; Medtronic, and 26 or 30 mm Saddle (Profile 3D; Medtronic). At 1 week post-repair, all animals underwent a follow-up MRI and echocardiography. The 4D PC MRI data was post-processed to remove static tissues, residual aliasing, and eddy currents. Blood flow velocity vectors were visualized using stream- and pathlines (CEI Ensight) and hemodynamics were qualitatively summarized. Peak transmitral flow velocity, pressure (modified Bernoulli equation) and the angle of the inflow jet were computed at the mitral valve vena contracta.
Mitral valve repair can result in significant mitral valve stenosis and abnormal LV hemodynamics.
The authors gratefully acknowledge support from the National Institutes of Health through awards K99HL108157 and R01HL63904.
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