Age-corrected measurement of extracellular volume fraction in remote normal myocardium is correlated with extent of risk area in AMI patients
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KeywordsInfarct Size Risk Area Gadolinium Contrast Remote Myocardium Inversion Recovery Sequence
Reduction of post-contrast T1 in remote normal myocardium was recently reported in patients with AMI, indicating that extracellular matrix expansion occurs in remote myocardium early after MI. Such extracellular matrix expansion observed in non-infarcted myocardium without edema seems to be one of key factors causing LV remodeling after MI. However, since the previous study only determined post-contrast T1, alteration of extracellular volume fraction (ECV) in remote myocardium early after MI is not investigated quantitatively. Consequently, we sought to quantify ECV in remote normal myocardium in AMI patients using T1 mapping before and after gadolinium contrast with hematocrit and heart-rate corrections, and investigate the association between ECV expansion in remote normal myocardium and extents of infarction and area at risk.
Sixteen reperfused AMI patients (13 men, 65 ± 13 years, 7.0 ± 2.5 days after onset), age- and sex-matched 16 OMI patients (4.1 ± 5.7years after onset) and age- and sex-matched 16 control subjects with normal CMR findings who underwent CMR including cine, T2WI (for AMI patients only), LGE and T1 mapping were retrospectively studied. T1 mapping was performed using a modified Look-Locker inversion recovery sequence. ECV was determined according to myocardial and blood T1 values measured before and after administration of gadolinium contrast and hematocrit measures. T1 values were corrected for heart rate. Risk size and infarct size was determined on T2WI and LGE images, respectively, in AMI patients. Age-related changes in T1 and ECV were also corrected using a least square fitted line obtained in control subjects.
ECV expansion up to 30% in remote normal myocardium occurs early after AMI onset and persists in chronic state. ECV expansion in remote normal myocardium is correlated with the extent of risk area in AMI patients.
I have no conflict of interest.
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