Comparison of methods for DE-CMR infarct size quantification - reproducibility among three core labs
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KeywordsAcute Myocardial Infarction Cardiovascular Magnetic Resonance Infarct Size Acute Myocardial Infarction Interobserver Reproducibility
Infarct size measurements with delayed-enhancement cardiovascular magnetic resonance (DE-CMR) are being used as surrogate endpoints in acute myocardial infarction (AMI) trials comparing therapeutic strategies. Semiautomated techniques using signal intensity thresholding are thought to be more reproducible than manual planimetry to define AMI borders. For both methods, endo-/epicardial borders are determined by manual planimetry, which was not considered in prior reproducibility studies. Visual scoring of AMI size based on a standard 17-segment, 5-point score is faster and does not require planimetry of endo-/epicardial borders. We compared the reproducibility of visual scoring, manual planimetry and semiautomated techniques.
Thirty patients with first AMI (58+/-11 years, 80% male), who underwent DE-CMR within 7 days after first elevated troponin test were enrolled. All scans were evaluated independently at each participating CMR core lab with at least three months temporal separation between analyses in the following manner: A) manual planimetry of the endo-/epicardial contours and infarct borders (MP), B) manual planimetry of endo-/epicardial contours, AMI size determined using a semiautomated technique with voxel weighting based on signal intensity, without user input (AUTO), C) same as B with user correction for no-reflow, artifact, etc. (AUTOcorrected), and D) visual scoring using a 17-segment, 5-point score (VISUAL). This comparison is based on a total of 30 measurements by three core-labs in four different manners for a total of 360 AMI size measurements.
Interobserver reproducibility was assessed using a) standard error of difference from mean (SED), and b) 1-intraclass-correlation coefficient (ICC). A SED<3 and 1-ICC<0.10 are considered excellent reproducibility.
Measures of Reproducibility
Standard error of difference (SED)
The interobserver reproducibility of manual planimtery, semiautomated techniques, and visual scoring for AMI size quantification is similar and excellent. Variability of semiautomated techniques is due to planimetry of endo-/epicardial borders.
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