Trabeculated (non-compacted) and compact myocardium in adults: the multi-ethnic study of atherosclerosis
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KeywordsCardiac Magnetic Resonance Multivariate Linear Regression Model Short Axis Image Apical Level American Ethnicity
A high degree of non-compacted (trabeculated) myocardium in relationship to compact myocardium (T/M ratio >2.3) has been associated with a diagnosis of left ventricular non-compaction (LVNC). The Multi-Ethnic Study of Atherosclerosis (MESA) is a population-based longitudinal study initiated in July 2000; with 6814 participants (45-84 years, 3601 women) free of recognized cardiovascular disease at enrollment. The purpose of this study was to determine the normal range of the T/M ratio in MESA and to examine the relationship to demographic and clinical parameters.
The thickness of trabeculation and the compact myocardium were measured in eight regions of the left ventricle on long axis cardiac magnetic resonance (CMR) steady-state free precession cine images in 1000 randomly chosen participants of the “MESA 5” follow-up cohort (551 women; 68.1±8.9 years) and T/M ratios were calculated.
Results of the current study suggest a reevaluation of the current CMR criteria for LVNC using a higher cut-off for T/M ratio and including the number of affected regions. A uniform definition of measurement technique is necessary.
This research was supported by contracts N01-HC-95159 through N01-HC-95169 from the National Heart, Lung, and Blood Institute.
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