In-vitro evaluation of a novel MR-compatible cardiac bioptome catheter for MR-guided myocardial biopsies
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KeywordsCardiac Magnetic Resonance Myocarditis Cardiac Magnetic Resonance Imaging Soft Tissue Contrast Acute Myocarditis
Retrieval of myocardial biopsies under X-ray guidance in patients with unclear myocardial dysfunction or acute myocarditis is a difficult and potentially hazardous procedure since soft tissues only offer low X-ray contrast during the procedure and extraction of biopsies could cause myocardial rupture and concomitant haemopericardium. In contrast, cardiac magnetic resonance imaging provides excellent soft-tissue and anatomic information, especially for inflamed and fibrotic areas. MR-guided myocardial biopsies would therefore be attractive but could not be performed until now due to incompatible bioptome catheters leading to substantial image artifacts and significant device heating.
Evaluation a novel MR-compatible bioptome in in-vitro experiments to assess potential artifacts, safety aspects and performance of MR-guided navigation under real-time imaging in a cylindrical 1.5T system.
The metal tip of the bioptome produced an artifact that allowed constant and precise ex-vivo tip localization. The artifact size was approximately 3.3x3 cm (figure 1(C),1(D)). The different structural elements of the heart and the target regions for the biopsy were clearly visible enabling a significantly better navigation of the tip than in conventional X-ray. The shaft of the bioptome caused no artifacts.
With the novel MR compatible bioptome, the superior CMR soft tissue visualization can be made available for MR-guided myocardial biopsies overcoming the limited soft tissue contrast on X-ray images. Clinically, this could significantly reduce the high amount of necessary specimen to overcome the sample error under X-ray and secondly improve the specificity and reliability of cardiac biopsies. Thirdly, MR-guided biopsies would minimize X-ray dose for the patient and especially the interventionalist.
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