Assessment of right and left ventricular trabeculation in a reference collective: gender and age dependency of myocardial trabeculation
KeywordsCardiac Magnetic Resonance Male Volunteer Cardiac Magnetic Resonance Imaging Female Volunteer Gender Dependency
Left ventricular non-compaction (LVNC) cardiomyopathy is characterized by a thin, compacted epimyocardial and a thick non-compacted, trabeculated endomyocardial layer. High-resolution cardiac magnetic resonance imaging (CMR) has been successfully used to distinguish myocardial trabeculation within the LV cavity. Usually, a compact-to-non-compact ratio of 2.3 on MRI is regarded pathological.
Unfortunately, this one-dimensional measure is not well standardized and observer-dependent. Moreover, only scarce data exists on age and gender dependency of myocardial trabeculation in normal volunteers
We present a novel multi-slice measurement approach for myocardial trabeculations and sought to investigate age and gender dependencies on LV and RV myocardial trabeculations.
In 120 male/female healthy volunteers divided into three age groups (1=20-35ys;2=36-50ys.;3=>51ys) a vector-ECG gated multi-slice short axis standard cine SSFP-sequence was used. Trabeculation volume was measured by drawing contours between compacted and non-compacted myocardium (outer solid line) as well as between edges of the trabeculation net and normal end-diastolic LV volume (inner dashed line) and normalized to body mass index (BMI). Papillary muscle were excluded. Data was compared using ANOVA (p<0.05 significant).
Interestingly, myocardial trabeculation is different between RV and LV. Though the LV trabeculation is independent from age for women and men, there is a significant decrease of trabeculation volume in the RV. Male volunteers always reveal higher trabeculation volumes for all age groups in both ventricles
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