LGE of left atrial ablation lesions: effect of imaging time on lesion visualization
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KeywordsLate Gadolinium Enhancement Atrial Fibrillation Patient Pulmonary Vein Isolation Late Gadolinium Enhancement Image Ablation Lesion
Late gadolinium enhancement (LGE) of radiofrequency (RF) ablation lesions in the left atrium (LA) is an emerging tool in the assessment of pulmonary vein isolation (PVI) of atrial fibrillation patients. Ablation lesions, however, may exhibit different pharmacokinetics to that of a myocardial infarction. Furthermore, due to the thin LA myocardium, blood-lesion CNR is critical to visualization. Consequently, we sought to study the effect of imaging time on lesion visualization, in patients imaged 1 day post PVI with 3D LGE.
Nine patients were imaged 1 day post PVI on a 1.5T Philips Achieva system, with a 5-channel cardiac coil (Philips Healthcare, Best, The Netherlands). Patients underwent 2 or 3 3D LGE scans (mean = 2.4±0.7) at times ranging from 12-43 minutes post administration of 0.2mmol/kg of Gd-DTPA (Magnevist, Bayer Healthcare). Details on 3D LGE imaging sequence can be found in . SNR and CNR (lesion-blood, and lesion-LV myocardium) measurements were made using ROIs in the anterior section of the left superior pulmonary vein (LSPV); the posterior wall and posterior section of the right superior pulmonary vein (RSPV). P-values were calculated from the correlation coefficients.
Result and discussion
In RF ablation lesion imaging using the LGE technique, it may be of benefit to image at later times in order to increase the CNR of the lesions with blood. The increase in CNR and SNR is likely to be due to the difference in the pharmacokinetics of the contrast agent in the lesion, in which uptake and wash-out are slower, compared to the pharmacokinetics inside the blood and healthy myocardium.
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