Cardiac magnetic resonance imaging (cMRI) as a first-line approach to subclinical heart failure in children undergoing cardiotoxic chemotherapy
- 436 Downloads
KeywordsCardiac Magnetic Resonance Iron Overload Paediatric Cancer Myocardial Iron Left Ventricular Stroke Volume
Cardiotoxic chemotherapy including anthracyclines remains a standard of care in paediatric cancers. Recent data suggest that heart failure secondary to chemotherapy is, to some degree, reversible, but requires early detection and prompt intervention. Since a substantial proportion of paediatric patients still develop heart failure, this work aims to develop a follow-up protocol based on cMRI to evaluate the patient’s cardiovascular function and haemodynamics, as well as myocardial iron overload, perfusion and viability.
Material and methods
From October 2009 to September 2010, 38 children (mean age 7,8 years (0,3-17,6); mean BSA of 0,98m2) were prospectively identified as candidates for cardiotoxic chemotherapy. All patients underwent a cMRI to evaluate 1) systolic and diastolic function on steady-state free precession cine and tagged imaging, 2) myocardial perfusion and viability after Gadolinium injections, 3) mitral and aortic flows through velocity-encoded sequences, and 4) myocardial and liver iron content based on T2* MRI.
The study protocol was completed in all patients within the first month of diagnosis, under general anaesthesia for the 14 youngest patients. The mean MRI acquisition time 40+/-9min. Systolic biventricular volumes, mass and function as well as left ventricular (LV) diastolic function were normal in all patients, with a mean LV EF of 62,2+/-8% and RV EF of 49,5+/-7,2%. Although a perfusion defect was not retrieved in any of these pre-chemotherapy assessments, mild LV myocardial scaring (mean of 4,5%) was frequently identified by gadolinium-enhanced imaging. Aortic and mitral flux showed normal LV stroke volumes (mean of 3,78L/min/m2). No significant liver or cardiac iron overload was detected (mean T2* of 23,6 and 33,2msec, respectively). Evaluation of the inter-observer and intra-observer variability was performed for all variables studied and confirmed that the coefficients of determination were very strong (R2>0,95), as previously reported by others.
Our preliminary study shows that a detailed cardiovascular evaluation of young patients undergoing chemotherapy is achievable in a reasonable time in the early phase following diagnosis. We believe that the low intra and inter-observer variability of cMRI makes it suitable for a complete mid- and/or long-term follow-up of cardiovascular function. This should allow to evaluate the true harmful effects of cardiotoxic medications used against paediatric cancers and to confirm the potential role of cMRI as a first-line approach to subclinical heart failure in children.
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.