Myocardial fibrosis is a prevalent finding in elite high-endurance athletes
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KeywordsLate Gadolinium Enhancement Myocardial Fibrosis Elite Athlete Late Gadolinium Enhancement Image Cardiac Morphology
Autopsies in athletes have shown that athletes have diffuse myocardial fibrosis, and epidemiological findings place athletes at a greater relative risk of sudden death due to cardiovascular causes. Electrocardiography abnormalities are well documented in athletes, where it is widely accepted that these are characteristic of the 'athlete's heart'. Furthermore, biochemical markers of collagen breakdown and myocardial fibrosis are elevated in athletes. As such, using CMR late Gadolinium enhancement (LE) imaging, we hypothesized that fibrosis is a feature of the athlete's heart and is associated with reduced cardiac function.
48 elite athletes (25 male, age 32 ± 13 years), and a control group of 8 healthy individuals (4 male, 31 ± 9 years) were prospectively recruited. On a 1.5 T MRI system, standard protocols for assessment for LV function and T1-weighted LE were performed.
Two experienced observers assessed LE images visually for the presence of fibrosis. The extent of fibrosis was assessed quantitatively, using semi-automated detection where regions that had signal enhancement above a threshold of 5 standard deviations from the mean signal of healthy myocardium, were considered to represent fibrosis. Areas that had a lack of contrast enhancement were used to define healthy myocardium.
Abbreviations utilized: LVEDVI – LV end-diastolic volume indexed-to-height; LVESVI – LV end-systolic volume indexed-to-height; LVSVI – LV stroke volume indexed-to-height; LVEF – LV ejection fraction
37 of 48 (77%) athletes had non-ischemic diffuse LE, compared with 1 of 8 (13%) of controls. The extent of myocardial fibrosis in athletes who had visual evidence for LE was 10.7 ± 3.3%. Athletes with fibrosis had increased LVEDVI (117 ± 19 vs. 98 ± 15 ml/m, p < 0.05), LVESVI (44 ± 11 vs. 34 ± 10 ml/m, p < 0.05), and LVSVI (73 ± 11 vs. 64 ± 7 ml/m, p < 0.05), while LVEF (63 ± 5 vs. 66 ± 6%, p > 0.05) did not differ, when compared to those who did not have fibrosis. Figure 1.
This is the first evidence of myocardial fibrosis being a prevalent finding in elite athletes, and its relation to cardiac morphology with depressed cardiac function. Long-term follow-up is required to assess the impact of fibrosis on outcome and prognosis in the 'athlete's heart'.
This article is published under license to BioMed Central Ltd.