2126 Saphenous vein graft atherosclerotic plaque quantification utilizing magnetic resonance imaging and multidetector computed tomography: a comparison with intravascular ultrasound
KeywordsMagnetic Resonance Imaging Atherosclerotic Plaque Magnetic Resonance Imaging Image Intravascular Ultrasound Multidetector Compute Tomography
The 10-year patency rate of saphenous vein grafts (SVG) has been reported to be 40%–60%. Atherosclerotic plaque has been implicated in this late stage of vein graft disease. We evaluated SVG plaque quantification by magnetic resonance imaging (MRI) and multidetector computed tomography (MDCT) as compared to intravascular ultrasound (IVUS).
To ascertain the feasibility and accuracy of plaque quantification utilizing MRI and MDCT as compared to IVUS.
Sequential patients (n = 22) undergoing coronary angiography with anginal symptoms and significant saphenous vein graft lesions were enrolled. All patients had IVUS, MDCT (16-detector) and MRI using black-blood T1-weighted imaging (1.5 T) performed. Cross-sectional images from IVUS and MDCT were analysed at 1 mm intervals along the entire length of the lesion. MRI images were obtained and analysed at 5 mm intervals. The sum of the plaque areas on these images gave the lesion volume. The MDCT and MRI images were analysed by two independent investigators. Spearman's correlation and Bland-Altman plots were used where appropriate.
Both black-blood MRI and MDCT are able to reliably quantify atherosclerotic plaque in SVGs when compared to IVUS. However, over estimation in plaque volumes is greater in MRI especially with increasing vessel size. The ability to noninvasively assess atherosclerosis in SVGs may potentially lead to superior risk prediction for future cardiovascular events.
This article is published under license to BioMed Central Ltd.