241 Cardiac T2* MRI at 3.0 Tesla for the detection of myocardial ischemia

  • Robert Manka
  • Cosima Jahnke
  • Bernhard Schnackenburg
  • Rolf Gebker
  • Eckart Fleck
  • Ingo Paetsch
Open Access
Meeting abstract
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Keywords

Coronary Artery Disease Coronary Artery Luminal Myocardial Ischemia Coronary Angiography 

Introduction

Alterations of myocardial oxygenation/microcirculation can be studied by measurements of the transverse relaxation time T2*, which represents a measure for the oxygenation level of hemoglobin.

Purpose

Purpose of this study was to evaluate the diagnostic performance of cardiac T2* measurements during adenosine stress for the detection of myocardial ischemia.

Methods

16 patients (mean age 63 ± 9 years, 6 female) suspected of having coronary artery disease and being scheduled for invasive coronary angiography underwent cardiac MR (CMR) imaging at 3.0 T (Philips Achieva, Best, NL). T2* measurements were performed in 3 short axis slices of the heart (6 echoes per slice) at rest and under adenosine stress (140 μg/kg/min over 6 min).

Quantitative coronary angiography served as standard of reference (significant luminal diameter narrowing ≥ 50%). Average T2* values of the myocardium were calculated from the mean value of the signal intensities in the ROI using the standard 16 segment model.

Results

7 patients (44%) had significant coronary disease; T2* measurement resulted in a sensitivity and specificity of 86% and 67%, respectively (patient based analysis; area-under-curve from ROC-analysis: 0.65).

Conclusion

Cardiac T2* measurements under adenosine stress at 3 T can detect myocardial ischemia in the presence of coronary artery stenosis.

Copyright information

© Manka et al; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.

Authors and Affiliations

  • Robert Manka
    • 1
  • Cosima Jahnke
    • 1
  • Bernhard Schnackenburg
    • 1
  • Rolf Gebker
    • 1
  • Eckart Fleck
    • 1
  • Ingo Paetsch
    • 1
  1. 1.German Heart Institute BerlinBerlinGermany

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