Bile duct adenoma: a case report and literature review
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Bile duct adenoma (BDA) is a comparatively rare disease clinically, therefore, there are relatively few reported cases about it both in China and abroad.
Herein, we present a 51-year-old man, diagnosed preoperatively with enhanced-contrast abdominal computed tomography, as having a nodule in the left hepatic. The patient underwent a liver tumor resection, and the histological examination revealed bile duct adenoma (BDA).
BDA is an extremely rare benign tumor, which is difficult to distinguish BDA from hepatocellular carcinoma definitely preoperatively, surgical resection is needed as a way of treatment.
KeywordsCholangiocarcinoma Arterial Phase Epithelial Membrane Antigen Liver Capsule Left Hepatic Lobe
Bile duct adenoma (BDA) is a comparatively rare disease clinically, therefore, there are relatively few reported cases about it both in China and abroad. Herein, we report a case of BDA as well as a literature review, thus presenting a preliminary analysis on BDA.
BDA is a rare case of benign intrahepatic tumor which is mostly found in patients between the age of 20 to 70 years old, averaging 55 years old, with no significant gender difference in the incidence of this disease . As the patients often do not present with clinical symptoms, this tumor is usually discovered by accident during a physical examination or an autopsy. It is the same case with the patient of this study: he was found to have liver occupying lesions unexpectedly when undergoing a chest CT examination.
Although BDA is defined as a benign tumor, it still has the possibility of carcinogenesis. Hasebe et al. reported a case in which BDA developed into cholangiocarcinoma . Through imaging examination, it is very hard to distinguish BDA from hepatocellular carcinoma definitely. Even when conducting a frozen section examination, it is still difficult to identify it from cholangiocarcinoma or liver metastasis. Therefore, surgical resection is still needed as a way of treatment and local excision is also feasible. Following surgical resection or local excision, patients have a good prognosis, and so far there is no report about tumor recurrence in the literature.
BDA is an extremely rare benign tumor, which is difficult to distinguish BDA from hepatocellular carcinoma through imaging examination .Its main character of pathological is a large quantity of proliferated bile ducts, which can be observed in the lesion,They are CK7, CK19, and EMA immunoreactive, and are p53 and Ki67 negative. Surgical resection is needed as a way of treatment.
Written informed consent was obtained from the patient for publication of this case and for the accompanying images.
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