Correlation of the ratio of metastatic to non-metastatic cancer cases with the degree of socioeconomic deprivation among Texas counties
Previous studies have demonstrated that cancer registrations and hospital discharge rate are closely correlated with census data-based socioeconomic deprivation indices. We hypothesized that communities with higher degrees of socioeconomic deprivation tend to have a higher ratio of metastatic to non-metastatic cancer cases (lung, breast, prostate, female genital system, colorectal cancers or all types of cancers combined). In this study, we investigate the potential link between this ratio and the Wellbeing Index (WI) among Texas counties.
Cancer data in 2000 were provided by the Texas Cancer Registry, while data on the ten socioeconomic variables among the 254 Texas counties in 2000 for building the WI were obtained from U.S. Census Bureau. The ten socioeconomic status variables were subjected to the principal component analysis, and the first principal component scores were grouped into deciles for the WI (1 to 10) and the 254 Texas counties were classified into 10 corresponding groups. Weighted linear regression analyses and a Cochran-Armitage trend test were performed to determine the relationship between the ratio of age-adjusted metastatic to non-metastatic cancer incidence cases and WI. The ratios of metastatic to non-metastatic cases of female genital system cancer (r2 = 0.84, p = 0.0002), all-type cancers (r2= 0.73, p = 0.0017) and lung cancer (r2= 0.54, p = 0.0156) at diagnosis were positively correlated with WI.
The ratios of metastatic to non-metastatic cases of all-type, female genital system and lung cancers at diagnosis were statistically correlated with socioeconomic deprivation. Potential mediators for the correlation warrant further investigation in order to reduce health disparities associated with socioeconomic inequality.
KeywordsInflammatory Breast Cancer Wellbeing Index Deprivation Index Female Genital System Socioeconomic Deprivation
Socioeconomic status is one of the major determinants of health status and health disparities among different social and ethnic groups , and may serve as a health indicator that has predictive value in spatial epidemiologic assessment. A critical issue is how to measure the socioeconomic status at the community level using readily available census information that might be used to predict health status using information from disease registries. Variables related to socioeconomic status from census data have been used for this purpose for community assessment [2, 3]. Having a reliable and easy means for performing area or community-wide assessments is useful for identifying targets for public health programs including cancer control activities. Crampton et al. developed the New Zealand Index of Relative Deprivation (NZDep91) which was constructed based on the percentages of people living in different communities meeting predefined socioeconomic deprivation criteria for nine variables derived from New Zealand census data . Others have developed similar deprivation indices based on US census data. Studies have shown that these deprivation indices are good predictors of health status [3, 4]. For example, Salmond et al. found that hospital discharge rate and mortality of all causes in the Wellington region and national cancer registrations for lung cancer in New Zealand were significantly and positively correlated with the NZDep91 . Singh reported that US mortality of all-causes was also significantly and positively correlated with a similar deprivation index derived from US census data .
The study reported here was undertaken to test a specific hypothesis that the ratio of metastatic to non-metastatic cancer cases (lung, breast, prostate, female genital system, colorectal cancers or all types of cancers) would be positively correlated with the degree of socioeconomic deprivation among Texas counties. Identifying cancer in its relatively earlier non-metastatic stages leads to substantially higher success in treatment and fewer cancer deaths. Such a difference is likely to exist among communities with different levels of socioeconomic deprivation as measured by a deprivation index. Texas is the second largest state in the United States of America with 261,797 square miles, larger than France . Texas has a projected population of 25,373,947 in 2010 ; its 77 urban counties have 80% of the population and the 177 rural counties contain the remaining 20%. Most Texas counties are classified as medically underserved with a limited infrastructure to support population health .
Variables used to build WI and the percentage of variance explained by each variable in its correlation with the first principal component (%)
People in households below poverty level
People over 18 without High school qualification
People in households without car
People in households without phone
People living in homes with too few bed rooms
People in single parent households
People with any disability
People with any form of support
People not living in own home
Data for the ten socioeconomic status variables for each of the 254 counties of Texas in 2000 were obtained from the U.S. Census Bureau . Data for cancer stages were provided by the Texas Cancer Registry, Cancer Epidemiology and Surveillance Branch, Texas Department of State Health Services . This database provides data by year, sex, county, etc. as well as population size for each county. We used cancer data of the year 2000 to be consistent with the 2000 US census data used to create the WI.
The ten socioeconomic status variables listed in Table 1 were subjected to a principal component analysis (PCA) with each of the 254 Texas counties as a unit following the PRINCOMP procedure of the SAS statistical package (Cary, NC). The first principal component scores of the 254 counties were grouped into deciles for the WI (from 1 to 10) and the 254 Texas counties were classified into 10 groups corresponding to the WI. Thus, each WI group contained 25 counties with the exception of 4 groups that had the highest PCA scores where 26 counties were assigned to each group. Carcinoma in situ and localized cancers were considered as non-metastatic while cancers defined as "regional, direct extension only", "regional, regional lymph nodes only", "regional, direct extension and regional lymph nodes", "regional, NOS" and "distant" were considered as metastatic. Note that our definition of metastasis is stringent, referring to cancers that had extended to adjacent or distant organs and tissues including lymph nodes, because prognoses are often significantly different . Weighted linear regression analysis (weighted by population size) and Cochran-Armitage trend test were performed with the SAS GLM and FREQ procedures, respectively, to determine the potential linear relationship between WI (explanatory continuous variable) and the ratio of metastatic to non-metastatic cancers (response variables) after adjustment for age with the 2000 U.S. standard population.
Before estimating the model, we compute the Moran's I statistic  and Geary's C statistic  in order to test for the existence of spatial autocorrelation in the regression residuals. If spatial autocorrelation is present in the residuals, then the parameter estimates are either biased or inconsistent . While Moran's I test provides a general test for global spatial autocorrelation, Geary's C test is more focused and sensitive to local effects or contiguity. Both statistics are computed using the 'spdep' package in R.
In addition, we performed principal component analysis with the percentages of people with cars, etc. rather than without cars etc. to construct a "reverse" WI, and found no correlation with the ratio of metastatic to non-metastatic cases of any cancer studied, suggesting that the WI is scaling deprivation but not wellbeing.
Correlation between Metastatic to Non-Metastatic Cancer Ratio and WI
Weighted Linear Regression Analysis
Tests for Spatial Correlation
Moran's I Test
Geary's C Test
Previous studies have demonstrated that several aspects of health problems such as mortality of all causes, lung cancer registrations and hospital discharge rate were closely correlated with census data-based deprivation indices [2, 4, 5, 15, 16]. Results of the current study adds to the literature a new aspect of health problems in relation to socioeconomic deprivation, demonstrating for the first time that the ratios of metastatic to non-metastatic cases of all types of cancer, lung cancer and the female genital system cancer were positively and significantly correlated with the WI among Texas counties. Several factors may have mediated the correlation such as the potentially higher environmental exposure to toxins, higher rate of obesity, and racial/ethnic composition associated with socioeconomic deprivation. In addition, potentially lower rates of health insurance coverage, cancer screening, and regular checkup, difficulties in transportation, and delay in seeking medical care etc. among counties with higher degree of socioeconomic deprivation [17, 18, 19, 20] may also be responsible for the correlation. Further investigations are warranted for the potential roles of these factors in mediating the correlation. Results from such investigations would provide crucial information for policy makers to take measures to reduce health disparities associated with socioeconomic inequality.
It should be noted that no significant correlation was found for breast, prostate and colorectal cancers. Although the exact reasons for the lack of correlation are unknown, several factors may be responsible. As pointed out above, one of the potentially significant mediators for the correlation may be lower cancer screening rates and or lower clinical checkup rate among counties with higher degree of deprivation. On the other hand, if the screening methods for certain types of cancers are not quite effective then one may or may not be able to detect significant correlation between WI and the ratio of metastatic to non-metastatic cancer cases. Recently, the U.S. Preventive Services Task Force no longer recommends screening mammography in women younger than 50 years old  because of high false-positive rates and low effects on mortality in spite of its widespread use . Similarly, "despite widespread adoption of PSA testing, however, it remains controversial. It has been shown that elevated PSA levels do not always indicate cancer and low PSA levels do not ensure that cancer is absent ." Thus, screening for breast and prostate cancers may not have increased early cancer detection rate so much among counties with better WI vs. those with worse WI as to reaching a threshold for a significant correlation. Another factor that may affect the ratio of metastatic to non-metastatic cancer cases is the large percentage of aggressive breast cancer types. In a recent study on 136 consecutive female patients with suspicious breast lesions detected by mammography-ultrasound-clinical examination triple assessment and finally diagnosed with breast cancer by histological examination, 79% (128) of the 162 lesions were grade 2 or 3 (with grade 3 as the most aggressive, fast-growing type of cancer) . Inflammatory breast cancer , anti-estrogen resistant breast cancer , and primary squamous cell carcinoma of the breast  are among the most aggressive breast cancers. As a result of the fast growing nature of this cancer, a large percentage of patients (62% in Texas as a whole) were diagnosed with breast cancer at late stages in spite of the wide utilization of screening in recent years. Since many had already developed late stage cancer with regular checkups, the potential advantage of regular checkup and screening may be compromised by the aggressiveness of this cancer.
In contrast, screening for colorectal cancer (CRC) is very effective . After detection of adenomatous polyps (not carcinoma yet) by screening, polypectomy is generally performed . If counties with better WI tend to have higher CRC screening rate, then two events may occur; (1) many CRC cases would be detected at early stage; (2) meanwhile, there may be a reduction in CRC cases at early stages as a result of polypectomy (otherwise polyps would have evolved to carcinoma at early stage first). Thus, polypectomy may have obscured the potential correlation between WI and the ratio of metastatic vs. non-metastatic cancer cases at diagnosis.
This study demonstrates the utility of the WI as a novel tool for identifying health disparities across large geographic areas. Further, this method can be accomplished in a relatively quick and reproducible fashion using readily available and standard census data. It would be of interest to apply the method to other disease pathologies.
Specific results for cancer pathologies show that the ratios of metastatic to non-metastatic cases of all-type cancers, lung cancer and the female genital cancer at diagnosis were significantly and positively correlated to WI among Texas counties. Hence, the WI is a useful indicator at least for the ratios of metastatic to non-metastatic cancer cases at county level. Further studies are needed to determine the actual sources and solutions for cancer in economically deprived areas. In particular, barriers for the early detection of cancers among communities with higher degree of socioeconomic deprivation should be examined in order to reduce health disparities.
Cancer incidence data have been provided by the Texas Cancer Registry, Cancer Epidemiology and Surveillance Branch, Texas Department of State Health Services, 1100 W. 49th Street, Austin, Texas, 78756, http://www.dshs.state.tx.us/tcr/default.shtm, or (512) 458-7523
- 1.Pamies RJP, Nsiah-Kumi PA: Addressing health disparities in the 21st century. Cultural proficiency in addressing health disparities. Edited by: Kosoko-Lasaki S, Cook CT, O'Brien RL. 2008, Boston: Jones and Bartlett Publishers, 1-35.Google Scholar
- 2.Crampton P, Salmond C, Sutton F: NZDep91: a new index of deprivation. Soc Policy J New Zealand. 1997, 9: 186-193.Google Scholar
- 7.Texas Department of State Health Services: Projected Texas Population by Area, 2010. Accessed 11/23/2010,http://www.dshs.state.tx.us/chs/popdat/ST2010.shtmhttp://www.dshs.state.tx.us/chs/popdat/ST2010.shtm
- 9.United States Census Bureau: Download Center: Census 2000 Summary File 1 (SF 1) 100-Percent Data. Accessed 01/31/2011,http://factfinder.census.gov/servlet/DCGeoSelectServlet?ds_name=DEC_2000_SF3_Uhttp://factfinder.census.gov/servlet/DCGeoSelectServlet?ds_name=DEC_2000_SF3_U
- 11.Hanrahan EO, Valero V, Gonzalez-Angulo AM, Hortobagyi GN: Prognosis and management of patients with node-negative invasive breast carcinoma that is 1 cm or smaller in size (stage 1; T1a,bN0M0): a review of the literature. J Clin Oncol. 2006, 24: 2113-2122. 10.1200/JCO.2005.02.8035.CrossRefPubMedGoogle Scholar
- 16.Rey G, Jougla E, Fouillet A, Hémon D: Ecological association between a deprivation index and mortality in France over the period 1997 - 2001: variations with spatial scale, degree of urbanicity, age, gender and cause of death. BMC Public Health. 2009, 9: 33-10.1186/1471-2458-9-33.PubMedCentralCrossRefPubMedGoogle Scholar
- 19.Sprague BL, Trentham-Dietz A, Gangnon RE, Ramchandani R, Hampton JM, Robert SA, Remington PL, Newcomb PA: Socioeconomic status and survival after an invasive breast cancer diagnosis. Cancer. 2010Google Scholar
- 21.U.S Preventive Services Task Force: Screening for breast cancer. Accessed 01/31/2011,http://www.uspreventiveservicestaskforce.org/uspstf/uspsbrca.htmhttp://www.uspreventiveservicestaskforce.org/uspstf/uspsbrca.htm
- 24.Costantini M, Belli P, Rinaldi P, Bufi E, Giardina G, Franceschini G, Petrone G, Bonomo L: Diffusion-weighted imaging in breast cancer: relationship between apparent diffusion coefficient and tumour aggressiveness. Clin Radiol. 2010, 65: 1005-1012. 10.1016/j.crad.2010.07.008.CrossRefPubMedGoogle Scholar
- 27.Gürsel B, Bayrak IK, Çakir S, Yildiz L, Gürsel M, Yücel I: Primary squamous cell carcinoma of the breast: A case report and review of the literature. Turk J Cancer. 2007, 37: 114-116.Google Scholar
- 28.Steinwachs D, Allen JD, Barlow WE, Duncan RP, Egede LE, Friedman LS, Keating NL, Kim P, Lave JR, Laveist TA, Ness RB, Optican RJ, Virnig BA: National Institutes of Health state-of-the-science conference statement: Enhancing use and quality of colorectal cancer screening. Ann Intern Med. 2010, 152: 663-667.CrossRefPubMedGoogle Scholar
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