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BMC Infectious Diseases

, 14:P39 | Cite as

Influence of hepatitis C virus on serum glutathione-S-transferase

  • Mircea Niculae Penescu
  • Corina-Daniela Ene (Nicolae)
  • Emanoil Ceauşu
  • Ilinca Nicolae
Open Access
Poster presentation

Keywords

Public Health Hepatitis Internal Medicine Glutathione Infectious Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Background

Glutathione-S-transferases (GST, E.C.2.5.1.18) are a family of enzymes that catalyze the conjugation of some harmful electrophilic compounds with glutathione, and thus, they are transformed in nontoxic lipophilic substances. In this study we aimed to evaluate the effect of hepatitis C virus on serum level of GSTpi in patients with active systemic lupus erythematous (SLE).

Methods

Serum level of GSTpi was quantified by immunoenzymatic method in 42 patients with active systemic lupus erythematous (based on SLEDAI score), without any treatment divided in two groups: Group A – 30 cases with active SLE (SLEDAI=11.2±3.2), with chronic C hepatitis; Group B – 12 cases with active SLE (SLEDAI=12.1±4.5) without hepatitis C. The results were compared to those obtained in the control group, which included 42 healthy subjects.

Results

We determined increased levels of GSTpi in patients with active SLE without C hepatitis, when compared with the control group (236±82 versus 211±68, p>0.05). In patients from group B, the level of GSTpi was statistically significant higher than in patients from group A (286±36 versus 236±82, p<0.05), respectively in control group (286±36 versus 217±39, p<0.05).

Conclusion

The increased levels of GSTpi in patients with SLE and chronic C hepatitis sustain the hypothesis that the release of this intracellular enzyme might be influenced by hepatitis C virus infection. This information might be useful for a better understanding of hepatitis C pathogenesis.

Copyright information

© Penescu et al; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Authors and Affiliations

  • Mircea Niculae Penescu
    • 1
  • Corina-Daniela Ene (Nicolae)
    • 1
  • Emanoil Ceauşu
    • 2
  • Ilinca Nicolae
    • 2
  1. 1.Carol Davila Clinical Hospital of NephrologyBucharestRomania
  2. 2.Clinical Hospital of Infectious and Tropical Diseases “Dr. Victor Babeş”BucharestRomania

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