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BMC Infectious Diseases

, 12:P69 | Cite as

Protective effect of KIR3DS1 in asymptomatic HIV-1 seroconverters towards AIDS

  • M Stalinraja
  • N Kalyanaraman
  • P Leishman
  • M Suresh
  • M Jayalakshmi
Open Access
Poster presentation

Keywords

Natural Killer Natural Killer Cell Human Leukocyte Antigen Killer Cell Killer Cell Immunoglobulin Like Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Background

The extreme variability at the Killer cell Immunoglobulin like Receptor (KIR) expressed on the surface of natural killer cells interacts with Human Leukocyte Antigen (HLA) Class I appear to play a crucial role in the outcome against viral infection. The combination of HLA/KIR gene products either individually or collectively have been implicated in the control of HIV-1 in various populations. Objective of this immunogenetic case-control study is to determine the association between KIR3DS1 and HIV-1 asymptomatism.

Methods

31 treatment naive HIV-1 asymptomatic (>3yrs without disease progression) and 31 HIV-1 seronegative ethnic matched healthy controls were recruited for this case – control study. Genomic DNA was extracted from peripheral blood by salting out procedure and KIR genotyping was performed for 16 KIR genes (Activating, Inhibitory and Pseudogenes) by Duplex PCR sequence-specific primer method.

Results

Overall, we observed 66.12 % of individuals with B KIR haplotype among case and controls group. Among the 16 KIR genes were typed KIR3DS1 (Activating KIR gene) shows significant variation among HIV asymptomatic individuals was 74.2 % whereas 54.8 % among controls.

Conclusion

Since, KIR3DS1 is well known for its effect on direct viral containment, presence of higher KIR3DS1 is one of the possible reasons for asymptomatism among this study cohort.

Copyright information

© Stalinraja et al; licensee BioMed Central Ltd. 2012

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Authors and Affiliations

  • M Stalinraja
    • 1
  • N Kalyanaraman
    • 1
  • P Leishman
    • 1
  • M Suresh
    • 2
  • M Jayalakshmi
    • 1
  1. 1.Dept of Immunology, School of Biological SciencesMadurai Kamaraj UniversityMadurai - 21India
  2. 2.ART CentreGovt Theni Medical College and HospitalTheniIndia

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