Modeling task-specific manifestations of serotonin in basal ganglia using risk-based decision making
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KeywordsBasal Ganglion Abstract Model Behavioural Inhibition Reward Sensitivity Future Reward
We propose a significant role of the reduced 5HT levels  in addition to DA to accurately explain the observed sensitivity profile  (Refer Fig. 1B). Shown here is that the 5HT-DA model (α > 0) captures the experiment profile  better than just a DA model of BG (α = 0). This model infers that 5HT along with DA contributes to the PD patients' reward-punishment sensitivity (Fig. 1A,B).
- 3.Bodi N, Keri S, Nagy H, Moustafa A, Myers CE, Daw N, Dibo G, Takats A, Bereczki D, Gluck MA: Reward-learning and the novelty-seeking personality: a between- and within-subjects study of the effects of dopamine agonists on young Parkinson's patients. Brain : a journal of neurology. 2009, 132 (Pt 9): 2385-2395.CrossRefGoogle Scholar
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