BMC Neuroscience

, 14:P428 | Cite as

A mathematical modeling perspective on the advantages of single receptor type convergence in the olfactory glomeruli

Open Access
Poster presentation
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Keywords

Olfactory Bulb Olfactory Receptor Input Pattern Mitral Cell Projection Pattern 

Olfactory circuits in both insects and rodents are wired according to a pattern of convergence in which axons from olfactory sensory neurons expressing a single receptor type (SRT) project into the same glomerulus. This permits the representation of individual olfactory receptors in a topographical map in the brain ([1], [2], [3]). The functional advantage offered by a SRT convergence pattern is an open question. We analyze a simple mathematical model based on the anatomy of the olfactory bulb. The model contains two interconnected layers of glomeruli and mitral cells. We use the mathematical model to qualitatively explore the impact on odor coding and discrimination by changing the projection pattern from SRT to multiple receptor type (MRT) input patterns. We predict that for odors activating similar patterns, the MRT network is not able to separate response patterns as well as the SRT network. The mathematical prediction is in good qualitative agreement with experimental findings. Our predictions also indicate that sparseness of input patterns and overall network size are key parameters in determining how well the SRT network performs in discrimination of odors. Future work will focus on verification of these additional predictions through biological experiments and also investigating the role of more realistic network models in influencing odor discrimination abilities of the SRT case.

References

  1. 1.
    Mombaerts P, Wang F, Dulac C, Chao SK, Nemes A, Mendelsohn M, Edmonson J, Axel R: Visualizing an olfactory sensory map. Cell. 1996, 87: 675-686. 10.1016/S0092-8674(00)81387-2.CrossRefPubMedGoogle Scholar
  2. 2.
    Resseler KJ, Sullivan SL, Buck LB: Information coding in the olfactory system: evidence for a stereotyped and highly organized epitope map in the olfactory bulb. Cell. 1994, 79: 1245-1255. 10.1016/0092-8674(94)90015-9.CrossRefGoogle Scholar
  3. 3.
    Vassar R, Chao SK, Sitcheran R, Nunez JM, Vosshall LB, Axel R: Topographic organization of sensory projections to the olfactory bulb. Cell. 1994, 79: 981-991. 10.1016/0092-8674(94)90029-9.CrossRefPubMedGoogle Scholar

Copyright information

© Chandrasekaran and Ron Yu; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Authors and Affiliations

  1. 1.Stowers Institute for Medical ResearchKansas CityUSA
  2. 2.Department of Anatomy and Cell BiologyUniversity of Kansas Medical CenterKansas CityUSA

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