BMC Neuroscience

, 12:P228 | Cite as

Identification of striatal cell assemblies suitable for reinforcement learning

  • Carlos Toledo-Suárez
  • Man Yi Yim
  • Arvind Kumar
  • Abigail Morrison
Open Access
Poster presentation

Keywords

Experimental Data Animal Model Basal Ganglion Computational Model System State 

Both in vivo [1] and in vitro [2] experimental data suggest that medium spiny neurons in striatum participate in the formation of sequentially firing cell assemblies, at a timescale relevant for the presumed involvement of basal ganglia in reinforcement learning. Computational models argue that such cell assemblies are a feature of a minimal network architecture of the striatum [3]. This suggests that cell assemblies can be a potential candidate for representation of the 'system states' in the framework of reinforcement learning.

Spike patterns associated with cells assemblies can be identified by clustering the spectrum of zero-lag cross-correlation between all pairs of neurons in a network [3]. Other methods based on the dimensionality reduction of the similarity matrix of the spike trains have also been used [2, 4].

Here we investigate how the identification of cell assemblies is dependent on the methodology chosen, and to what extent the statistical properties of the cell assemblies make them suitable for representation of system states in the striatum during reinforcement learning.

Notes

Acknowledgements

Partially funded by the German Federal Ministry of Education and Research (BMBF 01GQ0420 to BCCN Freiburg, BMBF GW0542 Cognition and BMBF 01GW0730 Impulse Control), EU Grant 269921 (BrainScaleS), Helmholtz Alliance on Systems Biology (Germany), Neurex, the Junior Professor Program of Baden-Württemberg and the Erasmus Mundus Joint Doctoral programme EuroSPIN.

References

  1. 1.
    Miller BR, Walker AG, Shah AS, Barton SJ, Rebec GV: Disregulated information processing by medium spiny neurons in striatum of freely behaving mouse models of Huntington's disease. J Neurophysiol. 2008, 100: 2205-2216. 10.1152/jn.90606.2008.PubMedCentralCrossRefPubMedGoogle Scholar
  2. 2.
    Carrillo-Reid L, Tecuapetla F, Tapia D, Hernández-Cruz A, Galarraga E, Drucker-Colin R, Bargas J: Encoding network states by striatal cell assemblies. J Neurophysiol. 2008, 99: 1435-1450. 10.1152/jn.01131.2007.CrossRefPubMedGoogle Scholar
  3. 3.
    Ponzi A, Wickens J: Sequentially switching cell assemblies in random inhibitory networks of spiking neurons in the striatum. J Neurosci. 2010, 30 (17): 5894-5911. 10.1523/JNEUROSCI.5540-09.2010.CrossRefPubMedGoogle Scholar
  4. 4.
    Sasaki T, Matsuki N, Ikegaya Y: Metastability of active CA3 networks. J Neurosci. 2007, 27 (3): 517-528. 10.1523/JNEUROSCI.4514-06.2007.CrossRefPubMedGoogle Scholar

Copyright information

© Toledo-Suárez et al; licensee BioMed Central Ltd. 2011

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Authors and Affiliations

  • Carlos Toledo-Suárez
    • 1
    • 2
    • 4
  • Man Yi Yim
    • 2
    • 3
  • Arvind Kumar
    • 2
    • 3
  • Abigail Morrison
    • 1
    • 2
  1. 1.Functional Neural Circuits Group, Faculty of BiologyUniversity of FreiburgGermany
  2. 2.Bernstein Center FreiburgUniversity of FreiburgGermany
  3. 3.Neurobiology and Biophysics, Faculty of BiologyUniversity of FreiburgGermany
  4. 4.Dept. Computational BiologySchool of Computer Science and Communication, KTHStockholmSweden

Personalised recommendations