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Cancer Imaging

, 14:P23 | Cite as

Use of textural analysis of tumour vascular heterogeneity as a biomarker of response to anti-angiogenic treatment in patients with nasopharyngeal carcinoma

  • Qiao Qi Teo
  • Benjamin Haaland
  • Choon Hua Thng
  • Wan Teck Lim
  • Tong San Koh
  • Quan-Sing Ng
Open Access
Poster presentation
  • 385 Downloads

Keywords

Random Forest Textural Analysis Pazopanib Tumour Blood Flow Gray Tone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Objectives

This study aims to evaluate the impact of tumour vascular heterogeneity, derived from textural analysis of dynamic contrast-enhanced computed tomography (DCE-CT) perfusion characteristics in patients with NPC treated with the anti-angiogenic drug, pazopanib.

Materials and methods

DCE-CT images of 33 patients, with recurrent/metastatic NPC treated with pazopanib, were analyzed to derive tumour blood flow, fractional intravascular blood volume, fractional extracellular-extravascular volume, and permeability surface area product. To each parametric map, textural analysis using multiple parameters based on co-occurrence matrix, neighbourhood gray tone difference, run-length matrix, gray level size-zone matrix and histogram statistics were applied to characterize its heterogeneity. Reproducible and important textures, were selected by a cut-off on the coefficient of variation and variable importance determined by random forest analysis, respectively. These textures are summarized by principal components analysis and their relationship to outcomes evaluated using Cox proportional hazards, receiver-operating characteristics, Kaplan-Meier and logistics regression analysis.

Results

The first principal component of the reproducible and important textural features of pre-treatment fractional intravascular blood volume (PC1) was related to survival outcomes. Using Kaplan Meier analysis, overall survival was significantly higher for patients with PC1 values greater than the median (p=0.002). There was no statistically significant association between DCE-textures and overall response.

Conclusion

Heterogeneity of tumour intravascular blood volumes may be an important biomarker for predicting overall survival in patients with NPC treated with anti-angiogenic therapy.

Copyright information

© Teo et al; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Authors and Affiliations

  • Qiao Qi Teo
    • 1
  • Benjamin Haaland
    • 1
  • Choon Hua Thng
    • 2
  • Wan Teck Lim
    • 3
  • Tong San Koh
    • 1
    • 2
  • Quan-Sing Ng
    • 3
  1. 1.Duke-NUS Graduate Medical SchoolSingaporeSingapore
  2. 2.Department of Oncologic ImagingNational Cancer Centre SingaporeSingaporeRepublic of Singapore
  3. 3.Department of Medical OncologyNational Cancer Centre SingaporeSingaporeRepublic of Singapore

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