Genetic management of infectious diseases: a heterogeneous epidemio-genetic model illustrated with S. aureus mastitis

  • Johann C. Detilleux
Open Access


Given that individuals are genetically heterogeneous in their degree of resistance to infection, a model is proposed to formulate appropriate choices that will limit the spread of an infectious disease. The model is illustrated with data on S. aureus mastitis and is based on parameters characterizing the spread of the disease (contact rate, probability of infection after contact, and rate of recovery after infection), the demography (replacement and culling rates) and the genetic composition (degree of relationship and heritability of the disease trait) of the animal population. To decrease infection pressure, it is possible to apply non-genetic procedures that increase the culling (e.g., culling of chronically infected cows) and recovery (e.g., antibiotic therapy) rates of infected cows. But the contribution of the paper is to show that genetic management of infectious disease is also theoretically possible as a control measure complementary to non-genetic actions. Indeed, the probability for an uninfected individual to become infected after contact with an infected one is partially related to their degree of kinship: the more closely they are related, the more likely they are to share identical genes like those associated to the non-resistance to infection. Different prospective genetic management procedures are proposed to decrease the contact rate between infected and uninfected relatives and keep the number of secondary cases generated by one infected animal below 1.


infectious disease resistance heterogeneous SIS model genetic management mastitis 

(To access the full article, please see PDF)

Copyright information

© INRA, EDP Sciences 2005

Authors and Affiliations

  1. 1.Quantitative Genetics Group, Department of Animal Production, Faculty of Veterinary MedicineUniversity of LiègeLiègeBelgium

Personalised recommendations