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EHMTI-0233. Clinical characteristics of migraine patients with dopaminergic gene polymorphisms RS1611115

  • K Skorobogatykh
  • J Azimova
  • A Sergeev
  • E Klimov
  • G Tabeeva
  • N Fokina
  • L Korobeynikova
  • Z Kokaeva
Open Access
Meeting abstract
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Keywords

Migraine Gene Polymorphism Genetic Susceptibility Polymorphism Rs1611115 Dopaminergic System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Introduction

The dopaminergic system plays a major role in migraine. Dopamine beta hydroxylase (DBH) is responsible for maintaining dopamine-to-norepinephrine ratio implicated in migraine pathophysiology. We aimed to look for association of polymorphisms in dopaminergic genes in genetic susceptibility to migraine in Russian population. In the present study DBH polymorphisms rs1611115 was selected.

The aim of this study was to determine whether the polymorphisms rs1611115 in DBH gene influenced any particular symptoms of the disease.

Methods

We have analyzed clinical characteristics of 128 patients with migraine (22 patients with migraine with aura and 106 patients with migraine without aura), according to the ICHD-II (2003)) taking into account their genotypes of TT variant of DBH. Genotyping was done using polymerase chain reaction (PCR).

Results

We have shown that the T-allele carriers (46,9%) as compared to the CC genotype patients (53,1%), have more severe coarse of migraine. A significant association was shown (number of acute medication per month (p=0.04), more severe grade of medication overuse (p=0.001), presence of allodinia (p=0.03) and prodrpomal period (p=0.001).

Conclusions

Thus, according to our data, the T-allele in rs1611115 is significantly associated with certain clinical characteristics of migraine.

No conflict of interest.

Copyright information

© Skorobogatykh et al; licensee Springer. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Authors and Affiliations

  • K Skorobogatykh
    • 1
  • J Azimova
    • 1
  • A Sergeev
    • 1
  • E Klimov
    • 2
  • G Tabeeva
    • 1
  • N Fokina
    • 1
  • L Korobeynikova
    • 3
  • Z Kokaeva
    • 2
  1. 1.University Headache ClinicUniversity Headache ClinicMoscowRussia
  2. 2.Department of GeneticsLomonosov Moscow State UniversityMoscowRussia
  3. 3.Department of GeneticsVavilov Institute of General Genetics of Russian Academy of SciencesMoscowRussia

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