Pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension with active Crohn’s disease
Anticoagulation control in active inflammatory bowel disease (IBD) is challenging because of hypercoagulation and bleeding complications. The strategy for treating chronic thromboembolic pulmonary hypertension (CTEPH) in IBD remains controversial because only a few studies have reported its successful treatment (Kim and Lang. Eur Respir Rev 21: 27-31, 2012, Bonderman, et al. Circulation 115: 2153-8, 2007). We describe a case of CTEPH with active Crohn’s disease successfully treated with pulmonary endarterectomy (PEA).
A 49-year-old man with CTEPH had undergone balloon pulmonary angioplasty four times; however, severe pulmonary hypertension remained. Moreover, he had Crohn’s disease, and sufficient anticoagulant therapy could not be performed because of frequent melena. He also had frequent episodes of intestinal ileus resulting in malnutrition. After strict anticoagulant control with warfarin, PEA was performed safely with strict control of the activated coagulation time. After PEA, his pulmonary hypertension improved to a normal range, and he underwent abdominal surgery for the recurrent intestinal ileus.
PEA for CTEPH with active IBD is challenging, but feasible. The strict anticoagulant control is critical for active IBD patients. Safety of taking direct oral anticoagulants is unclear because there are no parameters for monitoring the level of anticoagulation.
KeywordsChronic thromboembolic pulmonary hypertension Pulmonary endarterectomy Crohn’s disease Inflammatory bowel disease Balloon pulmonary angioplasty
Balloon pulmonary angioplasty
Chronic thromboembolic pulmonary hypertension
Direct oral anticoagulant
Inflammatory bowel disease
Pulmonary endarterectomy acquisition
The incidence of systemic thromboembolic events in inflammatory bowel disease (IBD) is higher than that in the general population, and IBD is now recognized as one of the risk factors for chronic thromboembolic pulmonary hypertension (CTEPH) [1, 2]. Anticoagulant therapeutic management in active IBD is controversial because of the complication of severe intestinal bleeding . Furthermore, patients with active IBD should be considered compromised hosts with malnutrition. In accordance with these factors, pulmonary endarterectomy (PEA) for CTEPH in IBD poses a great challenge to surgeons [1, 4]. Balloon pulmonary angioplasty (BPA) has been administered more frequently preoperatively and postoperatively in patients with CTEPH; however, its effectiveness is limited to distal lesions. Here, we describe a case of CTEPH with active Crohn’s disease successfully treated by PEA.
A 49-year-old man had been receiving medical treatment for CTEPH for 3 years. Although he had undergone BPA four times previously at another hospital before admission to our hospital, pulmonary hypertension persisted. He had also been treated for nontuberculous mycobacterial infection with antibiotics and Crohn’s disease with mesalazine (3000 mg/day). Despite this thorough treatment and strict nutritional control, he often experienced high fever and melena.
When he was admitted to our institution, his anticoagulant control was not sufficient because of malnutrition and bleeding complications. Since admission, he repeatedly developed high fever and melena owing to active Crohn’s disease. Given that melena occurred more frequently after the administration of direct oral anticoagulant (DOAC), the DOAC treatment was switched to anticoagulant therapy using warfarin with strict control of the low-level prothrombin international normalized ratio (range 1.5–2.0). Subsequently, melena was relieved. Two weeks before PEA, because of frequent intestinal ileus, he was placed on liquid nutritional supplementation to avoid intestinal inflammation.
Subsequently, the patient recovered completely and was transferred to the previous hospital to undergo surgical treatment for recurrent ileus. After subtotal colectomy, he was still doing well without any cardiovascular events during the 2-year follow-up.
Thromboembolic complications in IBD were first described in 1936 . Although deep vein thrombosis of the lower limbs and pulmonary embolism are the most common thromboembolic phenomena, thromboembolic complications in cerebral and retinal vessels, peripheral arteries, and portal and mesenteric veins have been reported [6, 7]. CTEPH has also been reported as a complication of IBD [1, 2]. Some factors including IBD have been recognized as risk factors for CTEPH development [1, 2, 4].
Active inflammation is associated with the onset of coagulability. Cytokines play a primary role in the pathogenesis of IBD and have a significant effect on the coagulation cascade. The interaction between inflammation and hemostasis affects the coagulation mechanism and platelet function [8, 9, 10]. The present patient had suffered from multiple diseases including active IBD, nontuberculous infection, and aspiration pneumonia resulting in active inflammation.
Spontaneous bleeding complications in active IBD make it difficult to treat thromboembolic phenomena. Although unfractionated heparin has been suggested for treating venous thrombosis in IBD, its role is controversial. Massive hemorrhage which requires emergency colectomy is seen in 3% of these patients . The safety of taking DOACs is also unclear because there are no parameters for monitoring the level of anticoagulation and there are no antagonists to reverse its effects. In the present case, frequent melena occurred after the administration of DOAC and the symptom was relieved after changing the anticoagulant therapy to warfarin with low-level prothrombin international normalized ratio control. Furthermore, strict control of the activated clotting time in a limited level during PEA prevented critical bleeding complications. Even after PEA, strict anticoagulation control using warfarin was necessary.
The patient in the present case frequently experienced melena and ileus. Thus, adequate nutritional replenishment including total parenteral nutrition should be considered in this case during the perioperative period. Despite these treatments, the patient showed malnutrition which made the anticoagulant therapy difficult. Infection control is also essential, because malnutrition is related to compromised host, and bacterial translocation occurs easily due to repeated intestinal paralysis in active IBD patients.
Additionally, BPA has been known as an effective endovascular treatment for CTEPH preoperatively and postoperatively; however, its effectiveness is limited to only distal lesions, and PEA is the most appropriate treatment for CTEPH with central lesions . In the present case, BPA performed four times was not effective, and only PEA improved his severe pulmonary hypertension to almost normal levels.
Performing PEA for CTEPH with active IBD is still challenging but feasible. Although the safety of taking DOACs is still unclear, strict anticoagulation control and multidisciplinary treatment including nutrition and infection control are also critical.
We would like to thank the staff from Honyaku Center for reviewing and editing the manuscript and our colleagues for their insightful comments.
We have no disclosures to make and we did not receive any financial support for this study.
Availability of data and materials
The data availability statement is present in this article.
All the authors equally took part in the conception of the case studies. KS, SS, and KM contributed to the acquisition of data. KS and TF contributed to the analysis. KS, SS, and KM contributed to the interpretation of data. KS contributed to the drafting and revising of the paper. All authors gave the final approval of the paper and agreed to be accountable for the integrity of the case reports. All authors read and approved the final manuscript.
Ethics approval and consent to participate
This case report was approved by the Institutional Review Board of Tokyo Medical University Hospital.
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The patient has provided permission to publish the features of his case. The identity of the patient has been protected.
The authors declare that they have no competing interests.
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- 11.Inami T, Kataoka M, Ando M, Fukuda K, Yoshino H, Satoh T. A new era of therapeutic strategies for chronic thromboembolic pulmonary hypertension by two different interventional therapies; pulmonary endarterectomy and percutaneous transluminal pulmonary angioplasty. PLoS One. 2014;9:e94587.CrossRefGoogle Scholar
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