Simultaneous resection of gastric and gallbladder metastasis from renal cell carcinoma treated by laparoscopic and endoscopic cooperative surgery: a case report
- 68 Downloads
Metastases to the stomach or gallbladder from any malignancy is rarely noted, and simultaneous metastases to both organs are atypical. We present a unique case of simultaneous multifocal metastases of the stomach and gallbladder from renal cell carcinoma (RCC).
The case involved a 60-year-old man, with a past history of RCC (clear cell type, G2, T1b N0 M0 Stage I) treated by a right nephrectomy. Three years after the nephrectomy, a routine gastrointestinal endoscopy found an ulcerative lesion in the greater curvature of the gastric body. The gastric tumor was pathologically proven to be a metastasis from RCC. Furthermore, computed tomography incidentally revealed a mass lesion in the fundus of the gallbladder, which was also diagnosed as a potential metastasis from RCC. As endoscopic ultrasonography of the gastric tumor suggested the tumor potentially invaded to the submucosal layer, gastric wedge resection via a laparoscopic and endoscopic cooperative surgery (LECS) technique was applied to the gastric tumor, and laparoscopic cholecystectomy to the gallbladder tumor was simultaneously performed. Histological examination confirmed that the tumors of the stomach and gallbladder were both metastatic RCC. The hospitalization period after surgery was not eventful, and the patient was discharged on postoperative day 7. Thereafter, the patient required examination every 3 months, did not use anticancer agents, and has survived without relapse to 9 months after the surgery.
For patients with locally resectable RCC metastases, complete metastasectomy may bring long-term tumor control. Moreover, LECS for gastric metastasis is a reasonable approach for minimal invasiveness and an oncologically feasible outcome.
KeywordsRenal cell carcinoma Gastric metastasis Laparoscopic and endoscopic cooperative surgery (LECS)
The incidence of renal cell carcinoma (RCC) has increased over the last decade in the USA and is estimated to be approximately 5% of all cancers . The rich vascular proliferation noted in RCC is thought to be the reason behind increased hematogenous spread leading to distant metastasis. One-third of cases are diagnosed with distant metastasis, for which the 5-year relative survival rate is 12% . The usual sites of RCC metastasis are well known such as the lung, bone, liver, adrenal gland, brain, and contralateral kidney; however, the stomach or gallbladder is rarely noted. Furthermore, simultaneous RCC metastasis to the stomach and gallbladder is an unique situation. Here, we present an unusual case of simultaneous metastasis of the stomach and gallbladder from RCC, treated by laparoscopic and endoscopic cooperative surgery (LECS) for gastric metastasis.
According to analysis obtained from autopsy specimens , the occurrence of metastasis to the stomach constitutes 5.4% of the total number of metastases from solid malignancies. Particularly, melanoma, lung cancer, breast cancer, and esophageal cancer are well known as common primary tumors; however, RCC is not. Likewise, in other large series studies [3, 4], RCC metastasis to the stomach is rarely mentioned; therefore, the frequency of occurrence is not yet clarified.
Although typical sites of RCC metastasis are the lung, bones, liver, lymph nodes, or adrenal glands, RCC metastasis to the stomach is quite a rare condition, and few case reports have been presented so far. When a PubMed search was performed to identify case reports written in English and published within the past three decades using the keywords “renal cell carcinoma,” “metastasis,” and “stomach,” only 31 case reports (excluding our case) and case series reports were detected [5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35]. Of those, as a larger case series repot, Sakurai et al.  entered details of 22 cases reported during a period from 2008 to 2012. Rita et al.  described the clinicopathological features and focused endoscopic therapy of 44 cases during a period from 1980 to 2014.
On the other hand, when searching the literature written in Japanese, 24 cases regarding gastric metastasis from RCC were reported in the past three decades, and Oizumi et al.  reviewed these clinicopathological features. In summary, most patients were male (92%) and the mean age was 65.9 (range 40–77, median 69). The time interval to detection of gastric metastasis from initial nephrectomy was 73 months (range 0–228, average 75, median 59). Most patients (71%) had remote metastasis of other organs, and only 7 patients (29%) were diagnosed as solitary gastric metastasis.
Our case exhibited simultaneous metastasis to the gallbladder as well. RCC metastasis to the gallbladder has been frequently reported comparatively; however, these findings are still a rare site of metastasis. To the best of our knowledge, our case is the first report to address simultaneous multifocal metastasis of the combination of stomach and gallbladder. As a similar situation to our present case, Kongnyuy et al.  recently reported simultaneous and multifocal metastases to ipsilateral left testes, bladder, and stomach from RCC, 7 years after a left nephrectomy.
Recent developments in laparoscopic surgical techniques and instruments enable a minimally invasive metastasectomy. Some researchers report laparoscopic total pancreatectomy for multiple RCC metastases in the pancreas was beneficial to patients . In our present case, gastric tumors were resected by a LECS technique. LECS is now the preferred treatment for gastric submucosal tumors  or duodenal tumors ; however, LECS experience in gastric metastatic tumors is limited due to its rarity. In our present case, LECS was adopted for the gastric tumor, as EUS suggested it potentially invaded to the submucosal layer. In a review describing endoscopic treatment for RCC gastric metastasis , surgical resection was performed in 39.5% of the patients. On the other hand, Japanese research describes treatment approaches for 22 patients with RCC gastric metastasis  and reports that endoscopic, surgical, and best supportive care were selected for 12, 8, and 4 patients, respectively. Although surgical treatment for these patients seemed to be highly limited, owing to the coexistence of other organ metastasis, interestingly, the patients who received a complete metastasectomy achieved a longer survival period. In the treatment for local metastases from RCC, no general guideline has yet reached consensus. In a recent systematic review, Dabestani et al.  concluded that complete metastasectomy substantially benefits patients’ survival and symptom palliation, with the assumption that their results were led by the retrospective studies included not those well-designed. Further analysis is needed to support our approach.
In summary, we experienced a rare case of simultaneous multifocal metastases of the stomach and gallbladder from RCC. Although it is still being discussed, for patients with locally resectable RCC metastases, complete metastasectomy may bring long-term tumor control. Moreover, LECS for the gastric metastasis is a reasonable approach with minimal invasiveness and an oncologically feasible outcome.
Availability of data and materials
OK participated in the design of this study and drafted the manuscript. OK, AI, and TY performed the laparoscopic surgery, and MD and YH performed the endoscopic technique. TK managed the postoperative examination of the patients. All the authors reviewed this manuscript and gave final approval for this version to be published.
Ethics approval and consent to participate
Consent for publication
The authors declare that they have no competing interests.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
- 1.Cancer Facts and Figures 2018. Atlanta, Georgia: American Cancer Society, 2018. Available online. Last accessed September 12, 2018.Google Scholar
- 10.Riviello C, Tanini I, Cipriani G, Pantaleo P, Nozzoli C, Poma A, et al. Unusual gastric and pancreatic metastatic renal cell carcinoma presentation 10 years after surgery and immunotherapy: a case report and a review of literature. World J Gastroenterol. 2006;12(32):5234–6.PubMedPubMedCentralGoogle Scholar
- 21.Namikawa T, Iwabu J, Kitagawa H, Okabayashi T, Kobayashi M, Hanazaki K. Solitary gastric metastasis from a renal cell carcinoma, presenting 23 years after radical nephrectomy. Endoscopy. 2012;44 Suppl 2:UCTN:E177–8.Google Scholar
- 27.Onorati M, Petracco G, Uboldi P, Redaelli DG, Romagnoli S, Albertoni M, et al. A solitary polypoid gastric metastasis 20 years after renal cell carcinoma: an event to be considered, and a brief review of the literature. Pathologica. 2013;5(4):132–6.Google Scholar
- 29.Kumcu E, Gönültas M, Ünverdǐ H, Hücümenoğlu S. Gastric metastasis of a renal cell carcinoma presenting as a polypoid mass. Endoscopy. 2014;46 Suppl 1:UCTN:E464.Google Scholar
- 33.O'Reilly MK, Sugrue G, Han-Suyin K, Fenlon H. Radiological, pathological and gross correlation of an isolated renal cell carcinoma metastasis to the stomach. BMJ Case Rep. 2017;2017:bcr-2017-220469.Google Scholar
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.