Critical Care

, 23:35 | Cite as

Is fluid resuscitation the “Keyser Soze” of acute kidney injury in trauma patients?

  • Matthieu JammeEmail author
  • Omar Ben Hadj Salem
Open Access

Dear Editor,

We read with great interest the study of Harrois et al. [1] that assessed the prevalence and risk factors of acute kidney injury (AKI) in trauma patients. In this large cohort, AKI was frequently observed, especially in patients admitted with hemorrhagic shock (42.5%) and was associated with hypoperfusion markers (blood lactate, minimum prehospital mean arterial pressure, maximum prehospital heart rate) and severity of trauma (hemorrhagic shock and higher Injury Severity Score). Interestingly, patients who required vasopressors did not develop more AKI, suggesting that in addition to renal ischemia, many different physiopathological pathways may be involved in AKI.

Due to these results, the authors have logically suggested systemic inflammation, rhabdomyolysis, renal parenchyma injuries, and ischemic tubulopathy as possible mechanisms leading to AKI. However, information concerning fluid administration during prehospital and hospital periods were not mentioned.

Although the use of colloids was recently restricted in the last European guidelines, due to hemostatic effects, for the benefit of crystalloids solutions [2], it is now well known that colloids are also nephrotoxic due to an accumulation of lysosomes in proximal tubular cells, also called osmotic nephrosis [3]. However, an excess of 0.9% NaCl solution administration causes hyperchloremia, a powerful vasoconstrictor agent of glomerular afferent arterioles and, i.e., a potential factor to extend renal ischemia [4]. Consequently, guidelines suggest to not use more than 1500 mL of 0.9% NaCl solution [2]. In case of head trauma, in which hypotonic solution should be avoided, fluid resuscitation becomes tricky.

Several promising studies had recently identified new potential therapeutic agents of ischemic tubulopathy [5] or rhabdomyolysis, which highlight the need for early identification of mechanisms underlying AKI.

In their report, the authors did not provide data concerning the volume of crystalloid administration, volume of colloid perfused, and indirect biomarker of a high infusion of crystalloid (high base deficit, hyperchloremia) or colloid (hypocalcemia). We hypothesize that these variables are possibly implicated with AKI following major bleeding.



Not applicable

Availability of data and materials

Not applicable

Authors’ contributions

MJ drafted the manuscript. OBHS helped to draft the manuscript. Both authors read and approved the final manuscript.

Ethics approval and consent to participate

Not applicable

Consent for publication

Not applicable

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.


  1. 1.
    Harrois A, Soyer B, Gauss T, Hamada S, Raux M, Duranteau J, et al. Prevalence and risk factors for acute kidney injury among trauma patients: a multicenter cohort study. Crit Care Lond Engl. 2018;22(1):344.CrossRefGoogle Scholar
  2. 2.
    Rossaint R, Bouillon B, Cerny V, Coats TJ, Duranteau J, Fernández-Mondéjar E, et al. The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition. Crit Care. 2016;20(1):100.CrossRefGoogle Scholar
  3. 3.
    Schortgen F, Brochard L. Colloid-induced kidney injury: experimental evidence may help to understand mechanisms. Crit Care. 2009;13(2):130.CrossRefGoogle Scholar
  4. 4.
    Wilcox CS. Regulation of renal blood flow by plasma chloride. J Clin Invest mars. 1983;71(3):726–35.CrossRefGoogle Scholar
  5. 5.
    Katsyuba E, Mottis A, Zietak M, De Franco F, van der Velpen V, Gariani K, et al. De novo NAD+ synthesis enhances mitochondrial function and improves health. Nature. 2018;563(7731):354–9.CrossRefGoogle Scholar

Copyright information

© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Authors and Affiliations

  1. 1.Intensive Care UnitPoissy Saint Germain HospitalPoissyFrance
  2. 2.INSERM U-1018, CESP, Team 5 (EpReC, Renal and Cardiovascular Epidemiology)UVSQVillejuifFrance
  3. 3.French Intensive Renal Network (FIRN)PoissyFrance

Personalised recommendations